Description

2-Chloro-4-(Trifluoromethyl)Pyrimidine-5-Carboxylic Acid is a high-value, multi-functional pyrimidine derivative that serves as a critical building block in advanced organic synthesis. Its molecular structure, featuring both a chloro and a trifluoromethyl substituent, makes it an essential intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system disorders, oncology, and infectious diseases.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Material Science Research: Serves as a monomer or functionalizing agent in the creation of specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Biology & Proteomics: Employed as a versatile scaffold for designing molecular probes, enzyme inhibitors, and labeled compounds for biochemical studies.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	2-Chloro-4-(Trifluoromethyl)Pyrimidine-5-Carboxylic Acid
CAS No.	188781-17-1
Molecular Formula	C6H2ClF3N2O2
Molecular Weight	226.54 g/mol
Synonyms	5-Pyrimidinecarboxylic acid, 2-chloro-4-(trifluoromethyl)-; 2-Chloro-4-trifluoromethylpyrimidine-5-carboxylic acid; 188781-17-1; 2-Chloro-4-(trifluoromethyl)-5-pyrimidinecarboxylic acid; 4-(Trifluoromethyl)-2-chloropyrimidine-5-carboxylic acid; 2-Chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate
EINECS	Contact for details

Quality Control

Our production of 2-Chloro-4-(Trifluoromethyl)Pyrimidine-5-Carboxylic Acid adheres to stringent quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF for moisture content. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with your internal specifications and cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if possible to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.