Description

4-Methyl-2-Chloro-Pyrimidine-5-Carboxylic Acid is a high-value pyrimidine derivative that serves as a critical building block in advanced organic synthesis. Its unique halogenated and carboxylated structure makes it an essential intermediate for constructing complex molecules with specific biological and chemical properties. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for developing active ingredients and novel compounds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for antiviral, anticancer, and kinase inhibitor drugs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and plant growth regulators.
• Chemical Research & Development: Serves as a versatile scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis.
• Material Science: Potential building block for creating specialty polymers, ligands for catalysis, or organic electronic materials.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds and development-scale batches.

Basic Information

Product Name	4-Methyl-2-Chloro-Pyrimidine-5-Carboxylic Acid
CAS No.	188781-10-4
Molecular Formula	C7H5ClN2O2
Molecular Weight	184.58 g/mol
Synonyms	2-Chloro-4-methylpyrimidine-5-carboxylic acid; 5-Carboxy-2-chloro-4-methylpyrimidine; 4-Methyl-2-chloropyrimidine-5-carboxylic acid; 188781-10-4; 2-Chloro-4-methyl-5-pyrimidinecarboxylic acid; 4-Methyl-2-chloro-5-pyrimidinecarboxylic acid; 2-Chloro-4-methyl-5-carboxypyrimidine
EINECS	Contact for details

Quality Control

Our 4-Methyl-2-Chloro-Pyrimidine-5-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications. We support cGMP standards for pharmaceutical applications and can accommodate custom purity requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.