Description

Fmoc-2-Aminobicyclo[2.2.1]heptane-2-carboxylic acid (mixture of isomers) is a specialized, non-natural amino acid derivative featuring a rigid bicyclic norbornane scaffold. This compound is critical for introducing conformational constraints into peptide chains, which is essential for studying structure-activity relationships and developing novel bioactive molecules. It is primarily utilized by researchers and manufacturers in pharmaceutical development, peptide synthesis, and medicinal chemistry for creating peptidomimetics and constrained peptides.

Application

• Peptide Synthesis & Medicinal Chemistry: As a key building block for incorporating a rigid, three-dimensional bicyclic structure into peptide backbones to enhance stability, selectivity, and biological activity.
• Pharmaceutical Research & Development: For the design and synthesis of novel peptidomimetics and drug candidates targeting GPCRs, enzymes, and other protein-protein interactions.
• Structure-Activity Relationship (SAR) Studies: To investigate the impact of backbone conformational restriction on peptide potency, metabolic stability, and receptor binding affinity.
• Combinatorial Chemistry & Library Synthesis: Used in the generation of focused chemical libraries for high-throughput screening to discover new lead compounds.
• Bioconjugation & Probe Development: The Fmoc-protected amino group allows for solid-phase synthesis, making it suitable for creating labeled peptides or bioconjugates for diagnostic and research applications.

Basic Information

Product Name	Fmoc-2-Aminobicyclo[2.2.1]heptane-2-Carboxylic Acid (Mixture Of Isomers)
CAS No.	188751-57-7
Molecular Formula	C23H23NO4
Molecular Weight	377.44 g/mol
Synonyms	Fmoc-2-Amino-2-norbornanecarboxylic acid (mixture of isomers); N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2-aminobicyclo[2.2.1]heptane-2-carboxylic acid; Fmoc-Abn-OH (mixture of isomers); Fmoc-2-Abn-OH; Nα-Fmoc-2-aminobicyclo[2.2.1]heptane-2-carboxylic acid; (1R,2S,4R)- and (1S,2R,4S)-N-Fmoc-2-aminonorbornane-2-carboxylic acid mixture; Fmoc-protected 2-aminonorbornane-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our Fmoc-2-Aminobicyclo[2.2.1]heptane-2-carboxylic acid is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, suitable for demanding research and development applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, isomer ratio, and impurity profiles. We adhere to relevant industry standards, and specifications can be tailored to meet specific project requirements for advanced peptide synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Isomer Ratio (by HPLC)	Specified on COA
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.