Description

5-Chloro-2-Fluorobenzyl Alcohol is a versatile fluorinated benzyl alcohol derivative that serves as a critical building block in advanced organic synthesis. Its value lies in the strategic positioning of chlorine and fluorine substituents, which enable precise molecular modifications and the introduction of unique physicochemical properties into target molecules. This intermediate is primarily needed by research and development chemists and process engineers in the pharmaceutical and agrochemical industries for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders and anti-infective agents.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, where the fluorine atom enhances biological activity and environmental stability.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing fluorinated aromatic compounds used in electronic display technologies.
• Polymer Modification: Employed to introduce functional benzyl groups into polymer chains, altering material properties like solubility and thermal stability.
• Cross-Coupling Reactions: The benzyl alcohol group can be transformed into various functionalities, making it a valuable substrate in Suzuki, Heck, and other palladium-catalyzed couplings.
• Protecting Group Chemistry: Utilized in multi-step synthetic routes where the alcohol moiety requires temporary protection and subsequent deprotection.

Basic Information

Product Name	5-Chloro-2-Fluorobenzyl Alcohol
CAS No.	188723-58-2
Molecular Formula	C7H6ClFO
Molecular Weight	160.57 g/mol
Synonyms	(5-Chloro-2-fluorophenyl)methanol; 2-Fluoro-5-chlorobenzyl alcohol; 1-(Chloro-5-fluoro-2)methanol; Benzenemethanol, 5-chloro-2-fluoro-; 5-Chloro-2-fluoro-benzenemethanol; α-Hydroxymethyl-5-chloro-2-fluorobenzene
EINECS	Contact for details

Quality Control

Our production of 5-Chloro-2-Fluorobenzyl Alcohol adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, GC for residual solvents, and NMR/IR for structural confirmation, to ensure consistency and reliability. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, detailing all critical quality attributes. Our facilities operate under cGMP principles where applicable, supporting development from preclinical through commercial scales.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its nature as an alcohol derivative that is easily oxidized (store under inert atmosphere), it is recommended to store under an inert atmosphere such as nitrogen or argon for long-term preservation. Keep away from heat, sparks, open flames, and strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.