Description

4-(Phosphonodifluoromethyl)-L-Phenylalanine is a specialized, non-natural amino acid derivative featuring a difluoromethylphosphonic acid group. This compound is a critical building block in medicinal chemistry, valued for its ability to introduce a metabolically stable, phosphate-mimicking moiety into peptide and small molecule structures. It is primarily sought by pharmaceutical researchers and fine chemical manufacturers for the development of novel therapeutics, including enzyme inhibitors and targeted biologics.

Application

• Pharmaceutical Intermediate: Key synthon for the development of protease inhibitors, kinase inhibitors, and other enzyme-targeted drugs.
• Peptidomimetic Design: Incorporation into peptide backbones to enhance metabolic stability, bioavailability, and binding affinity.
• Bioconjugation & Probe Development: Used in creating activity-based probes (ABPs) and affinity labels for studying enzyme function and mechanism.
• Chemical Biology Research: A versatile tool for mimicking phosphorylated tyrosine or for introducing a stable phosphonate isostere in biological systems.
• Agrochemical Research: Potential intermediate in the synthesis of advanced herbicides or plant growth regulators with novel modes of action.

Basic Information

Product Name	4-(Phosphonodifluoromethyl)-L-Phenylalanine
CAS No.	188642-79-7
Molecular Formula	C10H12F2NO5P
Molecular Weight	295.18 g/mol
Synonyms	L-4-(Difluorophosphonomethyl)phenylalanine; (2S)-2-Amino-3-[4-(difluorophosphonomethyl)phenyl]propanoic acid; F2Pmp-OH; Difluorophosphonomethyl-L-phenylalanine; 4-(Difluorophosphonomethyl)-L-Phe; Phenylalanine, 4-(phosphonodifluoromethyl)-, L-; F2Pmp; (S)-2-Amino-3-(4-((difluorophosphoryl)methyl)phenyl)propanoic acid
EINECS	Contact for details

Quality Control

Every batch of 4-(Phosphonodifluoromethyl)-L-Phenylalanine is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure identity, purity, and consistency for critical research and development applications. A detailed Certificate of Analysis (COA) including chiral purity (HPLC), assay, and impurity profile is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Assay (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee (L-isomer)
Water Content (KF)	≤ 1.0%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.