Description

Eptifibatide is a synthetic cyclic heptapeptide and a potent, selective antagonist of the platelet glycoprotein IIb/IIIa receptor. This compound is a critical active pharmaceutical ingredient (API) used to prevent platelet aggregation and thrombus formation. It is primarily required by pharmaceutical manufacturers for the production of injectable antithrombotic medications used in acute coronary syndrome and percutaneous coronary intervention procedures. Eptifibatide CAS NO 188627-80-7 represents a high-purity, well-characterized molecule essential for advanced cardiovascular therapies.

Application

• Active Pharmaceutical Ingredient (API): Primary use as the key therapeutic component in finished injectable drug formulations.
• Antiplatelet Drug Manufacturing: Synthesis of intravenous medications for the management of acute coronary syndromes (ACS).
• Cardiovascular Research: A standard reference compound in pharmacological studies targeting platelet aggregation pathways.
• GMP Pharmaceutical Production: Sourced by cGMP-compliant facilities for the commercial-scale manufacture of sterile injectables.
• Clinical Trial Material: Supplied as a qualified reference standard for bioequivalence and pharmacokinetic studies.
• Biochemical Reagent: Used in vitro as a specific inhibitor to study integrin αIIbβ3 (GPIIb/IIIa) function in cell biology.

Basic Information

Product Name	Eptifibatide
CAS No.	188627-80-7
Molecular Formula	C35H49N11O9S2
Molecular Weight	831.96 g/mol
Synonyms	Integrilin (Brand Name); Eptifibatide Acetate; MK-0852; N6-(Aminoiminomethyl)-N2-(3-mercapto-1-oxopropyl)-L-lysylglycyl-L-α-aspartyl-L-tryptophyl-L-prolyl-L-cysteinamide, cyclic(1→6)-disulfide; L-Cysteinamide, N6-(aminoiminomethyl)-N2-(3-mercapto-1-oxopropyl)-L-lysylglycyl-L-α-aspartyl-L-tryptophyl-L-prolyl-, cyclic (1→6)-disulfide; GP IIb/IIIa Inhibitor; Cyclo[S-(carboxymethyl)-L-cysteinyl-L-aspartyl-L-tryptophyl-L-prolyl-L-cysteinyl]amide
EINECS	Contact for details

Quality Control

Our Eptifibatide is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing including HPLC for purity and related substances, mass spectrometry for identity confirmation, and tests for residual solvents and elemental impurities to ensure compliance with ICH Q3 and pharmacopeial standards. Certificates of Analysis (COA) detailing all specifications and test results are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, 15-25°C, or as indicated on the label. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	≤ 20 ppm
Bacterial Endotoxins	< 5.0 EU/mg
Specific Rotation	-55° to -65° (c=1 in H2O)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.