Description

4-Arm-Peg-Sh is a multi-arm polyethylene glycol (PEG) derivative featuring a thiol (-SH) functional group at each terminus, with the CAS registry number 188492-68-4. This unique branched architecture provides a high density of reactive thiol sites, making it a critical building block for creating sophisticated, cross-linked hydrogel networks and functionalized surfaces. It is essential for researchers and manufacturers in the pharmaceutical and biomedical sectors who require precise control over material properties such as biodegradability, biocompatibility, and mechanical strength. Its primary value lies in enabling the development of advanced drug delivery systems, tissue engineering scaffolds, and diagnostic platforms.

Application

• Hydrogel Formation: Acts as a key cross-linking agent via thiol-ene or thiol-Michael addition reactions to create tunable, biocompatible hydrogels for 3D cell culture and tissue engineering.
• Drug Conjugation & Delivery: Used to conjugate therapeutic agents (e.g., proteins, peptides, small molecules) via its thiol groups, creating prodrugs or targeted delivery systems with controlled release profiles.
• Surface Functionalization: Enables the modification of gold nanoparticles, biosensor surfaces, and medical device coatings through strong Au-S or disulfide bonds for enhanced biocompatibility and specific targeting.
• Bioconjugation & Protein Modification: Serves as a versatile linker for site-specific protein PEGylation (multi-PEGylation) to improve pharmacokinetics, stability, and solubility of biologic drugs.
• Diagnostic Assay Development: Utilized in the fabrication of biosensors and diagnostic arrays where its multiple attachment points increase assay sensitivity and stability.
• Material Science Research: A fundamental reagent for synthesizing novel polymeric materials with tailored degradation rates, mechanical properties, and responsiveness to biological stimuli.

Basic Information

Product Name	4-Arm-Peg-Sh
CAS No.	188492-68-4
Molecular Formula	Contact for details
Molecular Weight	Variable (based on PEG arm length)
Synonyms	4-Arm PEG Thiol; Tetra-Arm PEG-SH; Four-Arm Polyethylene Glycol Thiol; PEG4-SH; Tetrathiol Functionalized PEG; Multi-Arm PEG Tetrathiol; Poly(ethylene glycol) tetra-thiol; Star-PEG-SH
EINECS	Contact for details

Quality Control

Our 4-Arm-Peg-Sh is manufactured under strict quality management protocols. Each batch undergoes rigorous analytical testing to ensure high purity, consistent functionality, and batch-to-batch reproducibility, meeting the stringent requirements for research and pharmaceutical development. Key parameters such as thiol content, degree of substitution, molecular weight distribution, and purity are verified. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic (moisture-sensitive) and easily oxidized nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C for long-term stability. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white waxy solid or viscous liquid
Identification (IR)	Conforms to structure
Assay (Thiol Content)	≥95% (by titration)
Purity (HPLC)	≥95%
Molecular Weight (Average)	As per customer grade (e.g., 5kDa, 10kDa, 20kDa)
Polydispersity Index (PDI)	≤1.05 (by GPC)
Water Content	≤1.0% (by KF titration)
Solubility	Soluble in water, DMSO, DMF, and common organic solvents

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.