Description

4-(1-Bromoethyl)-5-Fluoropyrimidine is a high-purity, halogenated pyrimidine building block of significant interest in advanced organic synthesis. This compound matters as a versatile intermediate for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce fluorinated pyrimidine motifs.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel fluorinated pyrimidine-based drug candidates, including potential kinase inhibitors and antiviral agents.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and pesticides where the fluoropyrimidine core can enhance biological activity and stability.
• Chemical Biology: Serves as a probe or labeling reagent in medicinal chemistry for structure-activity relationship (SAR) studies.
• Material Science Precursor: Can be utilized in the synthesis of specialized ligands or functional monomers for advanced polymers and materials.
• Cross-Coupling Reactions: The bromoethyl moiety makes it a suitable substrate for various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to create more complex structures.
• Nucleoside Analogue Synthesis: Acts as a precursor in the design and synthesis of modified nucleosides and nucleotides for therapeutic applications.

Basic Information

Product Name	4-(1-Bromoethyl)-5-Fluoropyrimidine
CAS No.	188416-47-9
Molecular Formula	C6H6BrFN2
Molecular Weight	205.03 g/mol
Synonyms	5-Fluoro-4-(1-bromoethyl)pyrimidine; 4-(1-Bromoethyl)-5-fluoropyrimidine; 5-Fluoro-4-(bromoethyl)pyrimidine; 4-(Bromoethyl)-5-fluoropyrimidine; 1-(5-Fluoropyrimidin-4-yl)ethyl bromide; 4-(α-Bromoethyl)-5-fluoropyrimidine; 188416-47-9; 5-Fluoro-4-(bromoethyl)pyrimidine
EINECS	Contact for details

Quality Control

Our 4-(1-Bromoethyl)-5-Fluoropyrimidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.