Description

(2R,3S/2S,3R)-3-(4-Chloro-5-Fluoro-6-Pyrimidinyl)-2-(2,4-Difluorophenyl)Butan-2-Ol Hydrochloride is a high-purity, non-racemic chiral building block and advanced pharmaceutical intermediate. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in the development of novel antifungal and other therapeutic agents. It is primarily required by pharmaceutical R&D laboratories, process chemists, and manufacturers engaged in the production of sophisticated, fluorinated drug candidates.

Application

• Key Intermediate for Antifungal APIs: Serves as a crucial chiral synthon in the multi-step synthesis of next-generation triazole and other antifungal medications.
• Pharmaceutical Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the discovery of new bioactive molecules.
• Process Chemistry & Scale-Up: Employed in the development and optimization of commercial-scale manufacturing routes for target drugs.
• Synthesis of Fluorinated Compounds: Its unique difluorophenyl and chloro-fluoropyrimidine groups make it a valuable precursor for introducing fluorinated motifs, which are prized in drug design for their metabolic stability and membrane permeability.
• Reference Standard: Can be utilized as a high-purity analytical standard for quality control and regulatory submissions.

Basic Information

Item	Details
Product Name	(2R,3S/2S,3R)-3-(4-Chloro-5-Fluoro-6-Pyrimidinyl)-2-(2,4-Difluorophenyl)Butan-2-Ol Hydrochloride
CAS No.	188416-35-5
Molecular Formula	C14H11ClF3N2O • HCl
Molecular Weight	359.61 g/mol
Synonyms	3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride; (2R,3S)- and (2S,3R)-Isomer mixture of 3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride; Fluorinated Pyrimidine Butanol Derivative; Antifungal Intermediate 188416-35-5; (2R,3S/2S,3R)-Isomer of Chloro-fluoro Pyrimidinyl Difluorophenyl Butanol HCl
EINECS	Contact for details

Quality Control

Our (2R,3S/2S,3R)-3-(4-Chloro-5-Fluoro-6-Pyrimidinyl)-2-(2,4-Difluorophenyl)Butan-2-Ol Hydrochloride is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity and impurity profile analysis by HPLC, to ensure it meets the exacting standards required for pharmaceutical development. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and compliance with client specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Isomeric Ratio)	≥ 99:1 (by chiral HPLC)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.