Description

6-(1-Bromo-Ethyl)-4-Chloro-5-Fluoropyrimidine is a high-purity, multi-functional halogenated pyrimidine building block essential for advanced organic synthesis. This compound matters because it provides a versatile reactive site for nucleophilic substitution and cross-coupling reactions, enabling the efficient construction of complex molecular architectures. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of antiviral, anticancer, and other small-molecule drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides.
• Chemical Research: Serves as a versatile building block in medicinal chemistry and process chemistry for structure-activity relationship (SAR) studies.
• Material Science: Potential precursor for the synthesis of specialized polymers and liquid crystals.
• Cross-Coupling Reactions: The bromo-ethyl moiety makes it a suitable substrate for Suzuki, Negishi, and other palladium-catalyzed coupling reactions.
• Nucleophilic Substitution: The chloro and fluoro substituents on the pyrimidine ring offer sites for selective displacement with various nucleophiles.

Basic Information

Product Name	6-(1-Bromo-Ethyl)-4-Chloro-5-Fluoropyrimidine
CAS No.	188416-30-0
Molecular Formula	C6H5BrClFN2
Molecular Weight	239.47 g/mol
Synonyms	4-Chloro-5-fluoro-6-(1-bromoethyl)pyrimidine; 4-Chloro-5-fluoro-6-(bromoethyl)pyrimidine; 6-(1-Bromoethyl)-4-chloro-5-fluoropyrimidine; 188416-30-0; 4-Chloro-5-fluoro-6-(α-bromoethyl)pyrimidine; Pyrimidine, 4-chloro-5-fluoro-6-(1-bromoethyl)-; 6-(Bromoethyl)-4-chloro-5-fluoropyrimidine
EINECS	Contact for details

Quality Control

Our 6-(1-Bromo-Ethyl)-4-Chloro-5-Fluoropyrimidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical characteristics is provided with every shipment to guarantee traceability and compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.