Description

2-Amino-5,6,7,8-Tetrahydro-3H-Pyrimido[4,5-B]Indol-4(9H)-One is a high-purity, advanced pharmaceutical intermediate belonging to the fused heterocyclic compound class. This compound is valued for its role as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs) and novel drug candidates. It is primarily sought by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, particularly within oncology and central nervous system (CNS) research.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of proprietary drug molecules and investigational new drugs (INDs).
• Oncology Research: Used in the development of targeted cancer therapies and kinase inhibitors due to its complex heterocyclic scaffold.
• CNS Drug Discovery: Serves as a core structure for synthesizing compounds targeting neurological disorders.
• Chemical Biology: Employed as a molecular probe or scaffold in structure-activity relationship (SAR) studies.
• Process Chemistry: Utilized in route scouting and scale-up optimization for API manufacturing under GMP conditions.
• Contract Research & Manufacturing (CRAM): Supplied to CROs and CDMOs for custom synthesis projects.

Basic Information

Product Name	2-Amino-5,6,7,8-Tetrahydro-3H-Pyrimido[4,5-B]Indol-4(9H)-One
CAS No.	188062-45-5
Molecular Formula	C10H12N4O
Molecular Weight	204.23 g/mol
Synonyms	2-Amino-4,5,6,7-tetrahydro-9H-pyrimido[4,5-b]indol-4-one; 2-Amino-4,5,6,7-tetrahydro-1H-pyrimido[4,5-b]indol-4(9H)-one; 2-Amino-4,5,6,7-tetrahydro-1H,9H-pyrimido[4,5-b]indol-4-one; 2-Amino-4,5,6,7-tetrahydro-1H-pyrimido[4,5-b]indol-4-one; 188062-45-5; Pyrimido[4,5-b]indol-4(9H)-one, 2-amino-5,6,7,8-tetrahydro-3H-; 2-Amino-5,6,7,8-tetrahydro-3H-pyrimido[4,5-b]indol-4(9H)-one
EINECS	Contact for details

Quality Control

Our 2-Amino-5,6,7,8-Tetrahydro-3H-Pyrimido[4,5-B]Indol-4(9H)-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D and manufacturing. Certificates of Analysis (COA) detailing batch-specific results are available upon request. We support compliance with cGMP, ICH Q7, and relevant pharmacopeial guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is moisture-sensitive (hygroscopic); keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.