Description

Fmoc-D-Arg(Pbf)-Oh CAS NO 187618-60-6 is a protected derivative of D-arginine, a non-natural amino acid enantiomer, specifically engineered for solid-phase peptide synthesis (SPPS). This high-purity building block is critical for researchers and manufacturers developing complex, chiral peptides with enhanced stability and specific biological activity. It is an essential raw material for pharmaceutical R&D, particularly in the production of therapeutic peptides, peptidomimetics, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid for the automated, stepwise construction of peptide chains.
• Pharmaceutical Research: Synthesis of novel therapeutic peptides targeting metabolic disorders, cardiovascular diseases, and oncology.
• Peptidomimetic Development: Incorporation of D-arginine to create protease-resistant analogs with improved pharmacokinetic properties.
• Bioconjugation & Labeling: Used to introduce arginine residues for chemical modification or fluorescent tagging in probe molecules.
• Antimicrobial Peptide (AMP) Studies: Research into AMPs containing D-amino acids to combat antibiotic resistance.
• Biochemical Reagent Production: Manufacture of high-purity substrates, inhibitors, and standards for enzymatic assays.

Basic Information

Product Name	Fmoc-D-Arg(Pbf)-Oh
CAS No.	187618-60-6
Molecular Formula	C33H47N5O7S
Molecular Weight	657.83 g/mol
Synonyms	Fmoc-D-arginine(Pbf)-OH; N-α-Fmoc-N-ω-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)-D-arginine; Fmoc-D-Arg(Pbf)-OH; (2R)-5-[[(2,2,4,6,7-Pentamethyl-2,3-dihydro-1-benzofuran-5-yl)sulfonyl]amino]-2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]pentanoic acid; D-Fmoc-Arg(Pbf)-OH; Fmoc-D-Arg(Pbf); N-α-(9-Fluorenylmethoxycarbonyl)-N-ω-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)-D-arginine
EINECS	Contact for details

Quality Control

Our Fmoc-D-Arg(Pbf)-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, typically ≥98.5% (by HPLC). Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. We support compliance with cGMP guidelines for advanced pharmaceutical intermediates, and specifications can be aligned with customer-specific pharmacopeial requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This material is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.5%
Chiral Purity (HPLC)	≥ 99.0% D-isomer
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.