Description

Fmoc-D-Arg(Pbf)-Oh is a high-purity, protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). This compound is critical for researchers and manufacturers requiring precise chirality and side-chain protection to ensure the successful and efficient construction of complex peptide sequences. It is primarily used by pharmaceutical R&D teams, biotechnology companies, and CROs/CDMOs focused on developing therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key building block for the automated, stepwise assembly of peptides, particularly where the D-arginine configuration is required.
• Therapeutic Peptide Development: For the research and production of novel peptide-based drugs targeting various diseases, where the Pbf (2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl) group protects the guanidino moiety of arginine.
• Bioconjugation and Probe Synthesis: In the creation of labeled peptides for diagnostic imaging, biomarker discovery, and biochemical assays.
• Antibiotic and Antimicrobial Peptide Research: For incorporating D-amino acids to enhance metabolic stability and biological activity of peptide leads.
• Custom Peptide Services: A fundamental reagent for contract research and manufacturing organizations (CROs/CDMOs) offering bespoke peptide synthesis.
• Academic & Institutional Research: Used in university and government labs for fundamental studies in biochemistry, medicinal chemistry, and structural biology.

Basic Information

Product Name	Fmoc-D-Arg(Pbf)-Oh
CAS No.	187618-60-0
Molecular Formula	C33H39N5O7S
Molecular Weight	649.76 g/mol
Synonyms	Fmoc-D-arginine(Pbf)-OH; N-α-Fmoc-N-ω-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)-D-arginine; Fmoc-D-Arg(Pbf)-OH; (2R)-5-[[(2,2,4,6,7-Pentamethyl-2,3-dihydro-1-benzofuran-5-yl)sulfonyl]amino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)pentanoic acid; D-Fmoc-Arg(Pbf)-OH; Fmoc-D-Arg(Pbf)-OH CAS 187618-60-0; N-α-(9-Fluorenylmethoxycarbonyl)-N-ω-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)-D-arginine
EINECS	Contact for details

Quality Control

Our Fmoc-D-Arg(Pbf)-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive); allow the sealed container to equilibrate to room temperature before opening to minimize condensation and moisture uptake. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% D-isomer
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.