Description

Sofigatran CAS NO 187602-11-5 is a high-purity, non-peptidic small molecule thrombin inhibitor. This compound is of significant interest in pharmaceutical research and development due to its potent and selective anticoagulant properties. It is primarily utilized by researchers and manufacturers in the pharmaceutical and biotechnology sectors for the development of novel antithrombotic therapies and as a critical reference standard in analytical laboratories.

Application

• Pharmaceutical R&D: Core active pharmaceutical ingredient (API) or intermediate in the development of novel oral anticoagulant drugs.
• Biochemical Research: A selective thrombin inhibitor used as a key tool compound in studying coagulation cascades, protease functions, and thrombosis mechanisms.
• Reference Standard: Serves as a certified reference material (CRM) for quality control, method validation, and regulatory submissions in analytical laboratories.
• Preclinical Studies: Used in in vitro and in vivo models to evaluate efficacy, pharmacokinetics, and safety profiles of antithrombotic agents.
• Chemical Synthesis: Acts as a sophisticated building block or intermediate for the synthesis of more complex thrombin-inhibiting molecules.

Basic Information

Product Name	Sofigatran
CAS No.	187602-11-5
Molecular Formula	C23H26FN5O4
Molecular Weight	455.48 g/mol
Synonyms	BIBR 953 ZW; BIBR-953; BIBR953; Dabigatran Etexilate Impurity; (2R)-2-[[(2S)-2-[[4-[[(Hexyloxy)carbonyl]amino]phenyl]methyl]-1-oxo-4-(pyridin-2-yl)butyl]amino]-3-(naphthalen-1-yl)propanoic acid; 1-Naphthalenepropanoic acid, α-[[(2S)-2-[[4-[[(hexyloxy)carbonyl]amino]phenyl]methyl]-1-oxo-4-(2-pyridinyl)butyl]amino]-, (αR)-
EINECS	Contact for details

Quality Control

Our Sofigatran is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identification by spectroscopic methods (IR, NMR, MS), to ensure it meets stringent specifications for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Chiral Purity	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.