Description

Fmoc-o-tert-Butyl-L-Tyrosinol CAS NO 187526-99-4 is a protected amino acid derivative, specifically an Fmoc-protected tyrosine analog with a tert-butyl ether protecting group on the phenolic hydroxyl. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled assembly of complex peptides and proteins. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors who require high-purity, protected intermediates for the development of peptide-based therapeutics, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc/tBu strategy, used in automated peptide synthesizers.
• Pharmaceutical Research & Development: Synthesis of peptide drug candidates, including hormone analogs, enzyme inhibitors, and antimicrobial peptides.
• Bioconjugation & Probe Development: Incorporation of a functionalizable tyrosine residue for labeling with fluorescent dyes, biotin, or other tags.
• Combinatorial Chemistry: Building block for creating diverse peptide libraries for high-throughput screening in drug discovery.
• Academic & Institutional Research: Fundamental studies in peptide chemistry, protein engineering, and structural biology.
• Contract Manufacturing (CMO/CDMO): Production of custom peptides and active pharmaceutical ingredients (APIs) under GMP conditions.

Basic Information

Product Name	Fmoc-o-tert-Butyl-L-Tyrosinol
CAS No.	187526-99-4
Molecular Formula	C28H29NO5
Molecular Weight	459.53 g/mol
Synonyms	Fmoc-Tyr(tBu)-ol; (2S)-3-(4-[(1,1-Dimethylethoxy)phenyl]-2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-1-propanol; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-tert-butyl-L-tyrosinol; Fmoc-L-Tyrosine(O-t-butyl)-ol; Fmoc-O-tert-butyl-L-tyrosine alcohol; Nα-Fmoc-O-tert-butyl-L-tyrosinol
EINECS	Contact for details

Quality Control

Our Fmoc-o-tert-Butyl-L-Tyrosinol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and spectroscopic identification (NMR, IR, MS). A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to ensure compliance with research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.