Description

(S)-2-(n-Fmoc-n-Methyl-Amino)-2-Cyclopentylacetic Acid CAS NO 187475-29-2 is a high-purity, non-natural amino acid derivative featuring a cyclopentyl side chain and an Fmoc-protected N-methyl amine group. This compound is a critical chiral building block for the synthesis of complex peptides and peptidomimetics, enabling the introduction of constrained, lipophilic structural elements. It is primarily utilized by pharmaceutical R&D and process chemistry teams for developing novel therapeutic agents, including protease inhibitors and other bioactive molecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid for the automated synthesis of custom peptides with enhanced metabolic stability and membrane permeability.
• Peptidomimetic Drug Discovery: Serves as a crucial scaffold for creating conformationally restricted analogs to improve potency, selectivity, and oral bioavailability of drug candidates.
• Pharmaceutical Intermediate: Used in the research and development of active pharmaceutical ingredients (APIs), particularly in oncology and metabolic disease research.
• Chemical Biology Probes: Employed in the synthesis of labeled or modified peptides for studying protein-protein interactions and enzyme mechanisms.
• Process Chemistry & Scale-Up: A validated starting material for the GMP-compliant production of peptide-based therapeutics at pilot and commercial scales.

Basic Information

Product Name	(S)-2-(n-Fmoc-n-Methyl-Amino)-2-Cyclopentylacetic Acid
CAS No.	187475-29-2
Molecular Formula	C23H25NO4
Molecular Weight	379.45 g/mol
Synonyms	Fmoc-N-Me-Cpg-OH; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-2-cyclopentylacetic acid; N-α-Fmoc-N-methyl-1-aminocyclopentane-1-carboxylic acid; Fmoc-N-methyl-1-aminocyclopentanecarboxylic acid; (S)-1-(Fmoc-N-methylamino)cyclopentanecarboxylic acid; Nα-(9-Fluorenylmethoxycarbonyl)-Nα-methyl-1-aminocyclopentanecarboxylic acid; Fmoc-N-Me-ACPC-OH
EINECS	Contact for details

Quality Control

Our (S)-2-(n-Fmoc-n-Methyl-Amino)-2-Cyclopentylacetic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric purity and NMR for structural confirmation, to ensure it meets the stringent requirements for pharmaceutical research and development. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.