Description

Ethyl 2-(Piperidin-1-Yl)-4-(Trifluoromethyl)Pyrimidine-5-Carboxylate is a high-value, functionalized pyrimidine derivative that serves as a critical advanced intermediate in modern synthetic chemistry. Its core value lies in the strategic combination of a piperidine moiety and a trifluoromethyl group, which are key pharmacophores for modulating the biological activity and physicochemical properties of target molecules. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries who are engaged in the discovery and synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of potential drug candidates, particularly in central nervous system (CNS), oncology, and anti-infective therapeutic areas.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances lipophilicity and metabolic stability.
• Chemical Biology Probe Synthesis: Employed to create molecular tools for studying enzyme function and biological pathways due to its versatile reactive sites.
• Material Science Precursor: Can be utilized in the synthesis of specialized ligands or organic components for advanced materials.
• Custom Synthesis & Contract Manufacturing: Serves as a starting material for custom synthesis projects requiring complex, multi-functional heterocycles.
• Academic & Institutional Research: Used in universities and research institutes for methodological studies in heterocyclic and fluorine chemistry.

Basic Information

Product Name	Ethyl 2-(Piperidin-1-Yl)-4-(Trifluoromethyl)Pyrimidine-5-Carboxylate
CAS No.	187036-01-7
Molecular Formula	C13H16F3N3O2
Molecular Weight	303.28 g/mol
Synonyms	Ethyl 2-(1-piperidinyl)-4-(trifluoromethyl)-5-pyrimidinecarboxylate; 5-Pyrimidinecarboxylic acid, 2-(1-piperidinyl)-4-(trifluoromethyl)-, ethyl ester; 2-Piperidino-4-trifluoromethyl-pyrimidine-5-carboxylic acid ethyl ester; Ethyl 2-piperidino-4-(trifluoromethyl)pyrimidine-5-carboxylate; 187036-01-7; 2-(Piperidin-1-yl)-4-(trifluoromethyl)pyrimidine-5-carboxylic acid ethyl ester
EINECS	Contact for details

Quality Control

Our Ethyl 2-(Piperidin-1-Yl)-4-(Trifluoromethyl)Pyrimidine-5-Carboxylate is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.