Description

Ethyl-4-Trifluoromethyl Pyrimidine-5-Carboxylate is a high-value fluorinated pyrimidine derivative, serving as a critical building block in advanced organic synthesis. Its core value lies in the unique reactivity imparted by the trifluoromethyl and ester functional groups, enabling precise molecular construction. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), especially in antiviral, anticancer, and central nervous system (CNS) drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and stability.
• Material Science Precursor: Serves as a starting material for synthesizing specialized ligands, catalysts, and fluorinated polymers with unique properties.
• Chemical Research & Development: Employed in academic and industrial R&D for exploring new heterocyclic chemistry, fluorination methodologies, and structure-activity relationships (SAR).
• Fine Chemical Production: Integral to the custom synthesis of complex, high-purity molecules for diagnostic and electronic chemical applications.

Basic Information

Product Name	Ethyl-4-Trifluoromethyl Pyrimidine-5-Carboxylate
CAS No.	187035-81-0
Molecular Formula	C8H7F3N2O2
Molecular Weight	220.15 g/mol
Synonyms	Ethyl 4-(trifluoromethyl)pyrimidine-5-carboxylate; 5-Pyrimidinecarboxylic acid, 4-(trifluoromethyl)-, ethyl ester; 4-Trifluoromethyl-pyrimidine-5-carboxylic acid ethyl ester; Ethyl 4-trifluoromethyl-5-pyrimidinecarboxylate; 187035-81-0; E4TMP5C; ETMPC
EINECS	Contact for details

Quality Control

Every batch of Ethyl-4-Trifluoromethyl Pyrimidine-5-Carboxylate is produced and tested under a strict quality management system to ensure consistency and reliability for your critical applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles as verified by advanced analytical techniques (HPLC, GC, NMR, IR). Our quality commitment aligns with cGMP principles where applicable, supporting your regulatory and research needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.