Description

Ethyl 2-Chloro-4-(Trifluoromethyl)Pyrimidine-5-Carboxylate is a high-value fluorinated pyrimidine building block essential for advanced organic synthesis. This compound is critical for the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where its unique trifluoromethyl and chloro substituents enable precise modulation of biological activity and physicochemical properties. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex heterocyclic scaffolds.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of potential drug candidates, particularly in kinase inhibitor and antiviral research.
• Agrochemical Development: Used in the research and production of advanced herbicides, fungicides, and insecticides that leverage the stability and lipophilicity of the CF3 group.
• Chemical Synthesis Building Block: Serves as a versatile precursor for further functionalization via cross-coupling reactions, nucleophilic substitutions, and hydrolysis to the corresponding acid.
• Material Science Research: Investigated for the creation of novel fluorinated organic materials and liquid crystals.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting drug discovery and development pipelines.

Basic Information

Product Name	Ethyl 2-Chloro-4-(Trifluoromethyl)Pyrimidine-5-Carboxylate
CAS No.	187035-79-6
Molecular Formula	C8H6ClF3N2O2
Molecular Weight	254.59 g/mol
Synonyms	2-Chloro-4-(trifluoromethyl)pyrimidine-5-carboxylic acid ethyl ester; Ethyl 2-chloro-4-trifluoromethylpyrimidine-5-carboxylate; 5-Pyrimidinecarboxylic acid, 2-chloro-4-(trifluoromethyl)-, ethyl ester; 187035-79-6; 2-Chloro-4-(trifluoromethyl)-5-pyrimidinecarboxylic Acid Ethyl Ester
EINECS	Contact for details

Quality Control

Our Ethyl 2-Chloro-4-(Trifluoromethyl)Pyrimidine-5-Carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical quality attributes to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and storage should minimize exposure to direct light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.