Description

Cortistatin-14 CAS NO 186901-48-4 is a synthetic peptide analog of the endogenous neuropeptide cortistatin, known for its potent biological activity. This compound is of significant interest for advanced research in neurobiology and endocrinology, particularly for studying sleep regulation, immune modulation, and neuronal excitability. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on developing novel therapeutic agents for neurological and inflammatory disorders.

Application

• Neuroscience Research: Investigation of sleep-wake cycles, cortical activity, and neuronal network functions.
• Immunology Studies: Exploration of anti-inflammatory pathways and immune system modulation.
• Drug Discovery: Serving as a reference standard or lead compound in the development of neuroactive pharmaceuticals.
• Biochemical Assays: Use in receptor binding studies and signal transduction pathway analysis.
• Academic & Preclinical Research: Fundamental studies on the physiological roles of cortistatin and related peptides.

Basic Information

Product Name	Cortistatin-14
CAS No.	186901-48-4
Molecular Formula	C81H123N25O22S2
Molecular Weight	1799.1 g/mol
Synonyms	Cortistatin-14 (human, rat); CST-14; hCST-14; Cortistatin (1-14); H-Ala-Pro-Ser-Ser-Arg-Pro-Leu-Pro-Pro-Arg-Pro-Arg-Cys-Arg-OH (disulfide bridge: Cys13-Cys14); Human Cortistatin-14; Rat Cortistatin-14; Somatostatin-related peptide
EINECS	Contact for details

Quality Control

Our Cortistatin-14 is manufactured under stringent conditions to ensure the highest standards of purity and consistency. Each batch undergoes comprehensive analytical testing, including HPLC for purity and MS for identity confirmation, to meet the exacting requirements of research and development. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. Due to its hygroscopic (moisture-sensitive) nature, the product should be kept under desiccated conditions and allowed to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Single Impurity (HPLC)	≤ 1.0%
Solubility	Soluble in water, acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.