Description

4-Fluoro-2-Hydroxybenzonitrile is a versatile fluorinated aromatic nitrile derivative, serving as a critical building block in advanced organic synthesis. Its molecular structure, featuring both a cyano and a hydroxyl group ortho to a fluorine atom, makes it a valuable precursor for constructing complex heterocycles and active pharmaceutical ingredients (APIs). This high-purity intermediate is essential for research and development chemists and process engineers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce fluorinated motifs into their target molecules.

Application

• Pharmaceutical Intermediate: Key synthon for the development of novel fluorinated drug candidates, particularly in kinase inhibitors and central nervous system (CNS) active compounds.
• Agrochemical Synthesis: Building block for creating advanced herbicides, fungicides, and pesticides where the fluorine atom enhances biological activity and environmental stability.
• Ligand and Catalyst Development: Used in the preparation of specialized ligands for metal-catalyzed cross-coupling reactions and other catalytic processes.
• Material Science Precursor: Intermediate in the synthesis of fluorinated liquid crystals, polymers, and advanced organic electronic materials.
• Chemical Research & Development: A versatile starting material for academic and industrial research exploring new fluorination methodologies and heterocyclic chemistry.

Basic Information

Product Name	4-Fluoro-2-Hydroxybenzonitrile
CAS No.	186590-01-2
Molecular Formula	C7H4FNO
Molecular Weight	137.11 g/mol
Synonyms	2-Cyano-5-fluorophenol; 5-Fluoro-2-hydroxybenzonitrile; 4-Fluoro-2-hydroxybenzenecarbonitrile; 2-Hydroxy-4-fluorobenzonitrile; 4-Fluoro-2-cyanophenol; 5-Fluorosalicylonitrile; 186590-01-2
EINECS	Contact for details

Quality Control

Our 4-Fluoro-2-Hydroxybenzonitrile is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, GC for residual solvents, and NMR/IR for structural confirmation, to ensure it meets the high standards required for synthetic applications. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.