Description

n-α-Allyloxycarbonyl-n-ε-(9-Fluorenylmethyloxycarbonyl)-L-Lysine CAS NO 186350-56-1 is a specialized, dual-protected derivative of the essential amino acid L-Lysine, designed for advanced peptide synthesis. This compound matters because it provides orthogonal protection strategies, allowing for selective deprotection of the alpha or epsilon amino groups during complex solid-phase and solution-phase peptide assembly. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel peptide-based therapeutics, diagnostics, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A critical building block for the controlled, sequential addition of lysine residues, enabling the synthesis of peptides with specific side-chain functionalities.
• Solution-Phase Peptide Chemistry: Used in classical coupling reactions where selective protection is required to prevent side reactions and ensure high-purity intermediate formation.
• Pharmaceutical Research & Development: Serves as a key intermediate in the R&D of peptide hormones, antimicrobial peptides, and targeted drug conjugates.
• Bioconjugation and Probe Development: Facilitates the site-specific attachment of labels, tags, or payloads to lysine residues within peptides or proteins.
• Combinatorial Chemistry Libraries: Employed in the generation of diverse peptide libraries for high-throughput screening against biological targets.
• Academic Research: Used in biochemistry and organic chemistry laboratories to study peptide structure, function, and synthesis methodologies.

Basic Information

Product Name	n-α-Allyloxycarbonyl-n-ε-(9-Fluorenylmethyloxycarbonyl)-L-Lysine
CAS No.	186350-56-1
Molecular Formula	C27H32N2O6
Molecular Weight	480.56 g/mol
Synonyms	Fmoc-Lys(Alloc)-OH; Nα-Alloc-Nε-Fmoc-L-lysine; N-Alloc-N'-Fmoc-L-lysine; Allyl N-(9H-fluoren-9-ylmethoxy)carbonyl-N6-[(allyloxy)carbonyl]-L-lysinate; Alloc-Lys(Fmoc)-OH; Fmoc-Lys(Alloc)-OH hydrate (common form); L-Lysine, N2-[(9H-fluoren-9-ylmethoxy)carbonyl]-N6-[(2-propen-1-yloxy)carbonyl]-
EINECS	Contact for details

Quality Control

Our n-α-Allyloxycarbonyl-n-ε-(9-Fluorenylmethyloxycarbonyl)-L-Lysine is manufactured under strict quality control protocols to ensure consistency and reliability for sensitive research and development applications. Each batch is analyzed to meet high-purity standards typical for peptide synthesis building blocks. Certificates of Analysis (COA) detailing purity, identity, and specific impurity profiles are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (IR)	Spectrum matches reference
Assay (HPLC)	≥98.0%
Optical Rotation [α]D20	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.