Description

2-(9H-Fluoren-9-Ylmethoxycarbonylamino)-3-Naphthalen-2-Yl-Propionic Acid is a specialized Fmoc-protected amino acid derivative, serving as a critical building block in advanced organic synthesis. Its primary value lies in enabling the precise construction of complex peptides and peptidomimetics, where the Fmoc group provides orthogonal protection for the amino functionality. This compound is essential for researchers and manufacturers in pharmaceutical development, particularly in solid-phase peptide synthesis (SPPS) for creating novel therapeutic agents and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid building block for the automated synthesis of custom peptides.
• Pharmaceutical Research & Development: Used in the discovery and production of peptide-based drugs, hormones, and diagnostic agents.
• Bioconjugation: Facilitates the site-specific labeling of proteins and other biomolecules for imaging and targeting studies.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening to identify new bioactive compounds.
• Academic & Industrial Research: A fundamental reagent for studying protein structure-function relationships and developing novel peptidomimetics.
• Synthesis of Non-Natural Amino Acids: Acts as a precursor for creating tailored amino acid analogs with modified properties.

Basic Information

Item	Details
Product Name	2-(9H-Fluoren-9-Ylmethoxycarbonylamino)-3-Naphthalen-2-Yl-Propionic Acid
CAS No.	186320-03-6
Molecular Formula	C28H23NO4
Molecular Weight	437.49 g/mol
Synonyms	Fmoc-2-Nal-OH; Fmoc-2-Naphthylalanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-(2-naphthyl)-L-alanine; Fmoc-L-2-Naphthylalanine; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(naphthalen-2-yl)propanoic acid; Nα-Fmoc-2-naphthylalanine; N-Fmoc-3-(2-naphthyl)-L-alanine; Fmoc-2-Nal
EINECS	Contact for details

Quality Control

Every batch of our 2-(9H-Fluoren-9-Ylmethoxycarbonylamino)-3-Naphthalen-2-Yl-Propionic Acid undergoes rigorous analytical testing to ensure it meets the stringent purity requirements for peptide synthesis. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as chiral purity, chemical purity, and residual solvent content. Our quality management system is designed to support GMP-compliant applications in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation and maintain optimal purity for sensitive synthetic applications.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-Isomer)
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.