Description

Amyloid β-Protein (1-14) is a synthetic peptide fragment corresponding to the first 14 amino acids of the human amyloid-beta protein. This compound is a critical research tool for studying the mechanisms of amyloid plaque formation, a key pathological hallmark in Alzheimer's disease and other neurodegenerative conditions. It is primarily utilized by researchers and pharmaceutical developers in the fields of neuroscience, biochemistry, and drug discovery for in vitro assays, antibody development, and structural studies.

Application

• Neuroscience Research: Fundamental studies on the aggregation kinetics, toxicity, and structural properties of amyloid-beta peptides.
• Drug Discovery & Screening: Used as a target or reference standard in high-throughput screening (HTS) assays to identify potential inhibitors of amyloid-beta aggregation.
• Antibody Development & Validation: Serves as a key antigen for the production, characterization, and quality control of diagnostic and therapeutic antibodies targeting amyloid-beta.
• Biochemical Assays: Employed in ELISA, Western blotting, and other immunoassays as a calibrator or control to study protein-protein interactions and signaling pathways.
• Academic & Institutional Research: Supports basic scientific investigations into the molecular basis of Alzheimer's disease and related dementias.
• Diagnostic Kit Manufacturing: Used as a raw material or reference standard in the production of in vitro diagnostic (IVD) kits for research use only (RUO).

Basic Information

Product Name	Amyloid β-Protein (1-14)
CAS No.	186319-74-4
Molecular Formula	C70H103N19O21
Molecular Weight	1526.7 g/mol
Synonyms	Amyloid β-Protein (1-14); Aβ (1-14); β-Amyloid (1-14); Amyloid Beta Peptide (1-14); DAEFRHDSGYEVHHQ; Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln; Aβ1-14; Amyloid-β (1-14) fragment
EINECS	Contact for details

Quality Control

Our Amyloid β-Protein (1-14) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and mass spectrometry (MS) for identity confirmation, to ensure it meets the high standards required for sensitive research applications. Certificates of Analysis (COA) detailing purity, peptide content, and analytical data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 70% (by weight)
Solubility	Soluble in water or dilute acetic acid
Water Content (K.F.)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.