Description

β-Amyloid (1-20) is a synthetic peptide fragment corresponding to the first 20 amino acids of the human amyloid-beta protein. This compound is a critical research tool for studying the mechanisms of Alzheimer's disease, particularly the aggregation and neurotoxicity of amyloid-beta peptides. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and diagnostic developers focused on neurodegenerative disorders and therapeutic target validation.

Application

• Neuroscience Research: Fundamental studies on amyloid-beta peptide aggregation kinetics, fibril formation, and oligomer toxicity.
• Drug Discovery & Screening: Serving as a key antigen or target in high-throughput assays to identify and evaluate potential inhibitors of Aβ aggregation.
• Antibody Development & Characterization: Used as an immunogen for generating antibodies or as a coating antigen in ELISA and other immunoassays to test antibody specificity.
• Biomarker Assay Development: Acting as a reference standard in the development and calibration of diagnostic assays designed to detect amyloid-beta fragments in biological samples.
• Structural Biology Studies: Utilization in NMR, X-ray crystallography, and other techniques to elucidate the structural properties of the Aβ peptide.
• Cell Culture & In Vitro Models: Application in cellular models to induce and study amyloid-related cytotoxicity and pathophysiological pathways.

Basic Information

Product Name	β-Amyloid (1-20)
CAS No.	186319-68-6
Molecular Formula	C100H140N28O31
Molecular Weight	2182.37 g/mol
Synonyms	Amyloid β-Protein (1-20); Aβ (1-20); Amyloid β-Peptide (1-20); β-Amyloid (1-20); DAEFRHDSGYEVHHQKLVFF; Amyloid Beta Fragment 1-20; Aβ1-20; Human Amyloid Beta Peptide 1-20
EINECS	Contact for details

Quality Control

Our β-Amyloid (1-20) is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation, and peptide content. We adhere to industry best practices, and specifications can be aligned with specific research or development project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Peptide Content	≥ 70%
Molecular Weight	2182.37 ± 2 Da
Solubility	Soluble in water or dilute acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.