Description

2-Amino-5-Chloro-3-Fluorophenol is a versatile halogenated aniline derivative that serves as a critical building block in advanced organic synthesis. Its unique substitution pattern makes it a valuable intermediate for creating complex molecules with tailored properties. This compound is primarily utilized by research and development chemists and process engineers in the pharmaceutical and agrochemical industries for the synthesis of active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for compounds targeting central nervous system and anti-infective applications.
• Agrochemical Synthesis: Building block for developing advanced herbicides, fungicides, and pesticides, leveraging the fluorine and chlorine atoms for enhanced bioactivity and environmental stability.
• Dye and Pigment Manufacturing: Intermediate in the production of specialized azo dyes and high-performance pigments where halogen atoms improve lightfastness and color properties.
• Material Science Research: Used in the development of organic electronic materials, liquid crystals, and polymers requiring specific halogenated aromatic cores.
• Cross-Coupling Reactions: Serves as a substrate in Suzuki, Buchwald-Hartwig, and other palladium-catalyzed coupling reactions to construct biaryl and complex aromatic systems.
• Chemical Research & Development: A valuable reagent for medicinal chemistry and process chemistry teams exploring new synthetic routes and molecular entities.

Basic Information

Product Name	2-Amino-5-Chloro-3-Fluorophenol
CAS No.	186309-72-8
Molecular Formula	C6H5ClFNO
Molecular Weight	161.56 g/mol
Synonyms	5-Chloro-3-fluoro-2-aminophenol; 2-Amino-5-chloro-3-fluorophenol; 3-Fluoro-5-chloro-2-aminophenol; 1-Amino-4-chloro-6-fluoro-2-hydroxybenzene; 2-Hydroxy-6-chloro-4-fluoroaniline; 5-Chloro-3-fluoro-2-hydroxyaniline; Phenol, 2-amino-5-chloro-3-fluoro-; 186309-72-8
EINECS	Contact for details

Quality Control

Our 2-Amino-5-Chloro-3-Fluorophenol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via FT-IR and NMR spectroscopy, to ensure it meets the high standards required for synthetic applications. Certificates of Analysis (COA) with full traceability are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its light-sensitive nature and propensity for oxidation, it is recommended to store under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	125 - 130 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.