Description

Fmoc-Pna-G(Bhoc)-Oh CAS NO 186046-83-3 is a protected amino acid derivative, specifically an Fmoc/Bhoc-protected glutamic acid analog, designed for advanced solid-phase peptide synthesis (SPPS). This compound is critical for constructing complex peptides with high precision and minimal side reactions, ensuring the integrity of the peptide backbone. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic peptides, peptide-based diagnostics, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key building block for the controlled, sequential assembly of custom peptides in automated synthesizers.
• Pharmaceutical Research & Development: Used in the synthesis of peptide drug candidates, including hormone analogs, enzyme inhibitors, and targeted therapeutics.
• Bioconjugation and Probe Development: Serves as a modified amino acid precursor for creating labeled peptides used in imaging, diagnostics, and affinity studies.
• Combinatorial Chemistry Libraries: Employed to generate diverse arrays of peptide sequences for high-throughput screening against biological targets.
• Academic Research: Fundamental tool for studying protein-protein interactions, enzyme mechanisms, and structural biology.
• Process Development & Scale-Up: Supports the transition from milligram-scale research to gram or kilogram-scale production for clinical trial materials.

Basic Information

Product Name	Fmoc-Pna-G(Bhoc)-Oh
CAS No.	186046-83-3
Molecular Formula	C₂₆H₂₈N₂O₈
Molecular Weight	496.51 g/mol
Synonyms	Fmoc-Glu(Bhoc)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-glutamic acid 5-(1,1-dimethylethyl) 1-(2,2-dimethyl-1-oxopropoxy) ester; Fmoc-L-glutamic acid 5-tert-butyl 1-(2,2-dimethylpropanoyl) ester; Fmoc-Glu(OtBu)-OH derivative; Bhoc-protected Fmoc-glutamic acid; (S)-5-((tert-Butoxycarbonyl)amino)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-5-oxopentanoic acid; Protected Fmoc-Glutamate
EINECS	Contact for details

Quality Control

Our Fmoc-Pna-G(Bhoc)-Oh is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for fine chemicals used in pharmaceutical research, ensuring material suitability for GLP and GMP environments upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 98.0%
Specific Rotation	-15.0° to -18.0° (c=1 in DMF)
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.