Description

Fmoc-Pna-A(Bhoc)-Oh CAS NO 186046-82-2 is a specialized, orthogonally protected amino acid derivative designed for advanced solid-phase peptide synthesis (SPPS). This compound is critical for enabling complex peptide assembly by providing selective deprotection strategies, which is essential for synthesizing challenging sequences and cyclic peptides. It is primarily needed by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on developing novel peptide-based therapeutics, diagnostics, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key building block for the controlled, sequential assembly of peptides, particularly useful for synthesizing long or complex sequences.
• Pharmaceutical Research & Development: Used in the discovery and development of novel peptide drugs, including hormone analogs, antimicrobial peptides, and targeted therapeutics.
• Combinatorial Chemistry Libraries: Employed to create diverse arrays of peptide compounds for high-throughput screening against biological targets.
• Bioconjugation and Probe Synthesis: Serves as a precursor for creating labeled peptides (e.g., fluorescent, biotinylated) used in biochemical assays and diagnostic applications.
• Academic Research: Utilized in university and institutional labs for studying peptide structure, function, and folding mechanisms.
• Production of Custom Peptides: A critical raw material for contract research and manufacturing organizations (CROs/CMOs) offering custom peptide synthesis services.

Basic Information

Product Name	Fmoc-Pna-A(Bhoc)-Oh
CAS No.	186046-82-2
Molecular Formula	C30H30N2O7
Molecular Weight	530.57 g/mol
Synonyms	Fmoc-4-Amino-D-phenylalanine(Bhoc)-OH; N-α-Fmoc-N-β-(2,2-dimethyl-2H-benzopyran-6-sulfonyl)-D-2,4-diaminobutanoic acid; Fmoc-D-Dap(Bhoc)-OH; Fmoc-D-2,4-diaminobutyric acid(Bhoc); (2R)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-4-[(2,2-dimethyl-4-oxo-4H-1,3-benzodioxin-6-yl)sulfonylamino]butanoic acid; Fmoc-D-Dab(Bhoc)-OH; Bhoc-protected D-diaminobutyric acid Fmoc derivative
EINECS	Contact for details

Quality Control

Our Fmoc-Pna-A(Bhoc)-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive research and production applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and chiral analysis to verify enantiomeric integrity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (D-isomer)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.