Description

Fmoc-Pna-C(Bhoc)-Oh CAS NO 186046-81-1 is a specialized, orthogonally protected amino acid derivative designed for advanced solid-phase peptide synthesis (SPPS). This compound is critical for constructing complex peptides and peptidomimetics, offering precise control over side-chain reactivity during sequential assembly. It is an essential building block for researchers and manufacturers in pharmaceutical development, particularly for creating novel therapeutic peptides, diagnostic agents, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid for the automated, sequential assembly of custom peptide sequences.
• Pharmaceutical R&D: For the discovery and development of peptide-based drugs targeting GPCRs, enzymes, and other biological pathways.
• Peptidomimetic Design: Enables the incorporation of non-natural amino acid structures to enhance metabolic stability and binding affinity of lead compounds.
• Combinatorial Chemistry Libraries: Used in the generation of diverse peptide libraries for high-throughput screening against biological targets.
• Bioconjugation & Labeling: Serves as a precursor for synthesizing peptide conjugates with dyes, tags, or drug molecules for diagnostic and therapeutic applications.
• Academic & Institutional Research: A fundamental reagent for studies in chemical biology, biochemistry, and medicinal chemistry.

Basic Information

Item	Details
Product Name	Fmoc-Pna-C(Bhoc)-Oh
CAS No.	186046-81-1
Molecular Formula	C31H32N2O7
Molecular Weight	544.60 g/mol
Synonyms	Fmoc-Pna-C(Bhoc)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-[[(1,1-dimethylethoxy)carbonyl]amino]-L-phenylalanine; Fmoc-3-[(Boc)amino]-L-phenylalanine; Fmoc-L-Phe(3-NHBoc)-OH; Fmoc-3-(Boc-amino)-L-phenylalanine; Nα-Fmoc-Nβ-Boc-2,3-diaminopropionic acid derivative; (2S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-[3-[(2-methylpropan-2-yl)oxycarbonylamino]phenyl]propanoic acid
EINECS	Contact for details

Quality Control

Our Fmoc-Pna-C(Bhoc)-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and chiral analysis to ensure enantiomeric integrity. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee compliance with your research and cGMP-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.