Description

Fmoc-Val-Ser(Psime,Mepro)-Oh CAS NO 186023-49-4 is a specialized, orthogonally protected dipeptide building block designed for advanced solid-phase peptide synthesis (SPPS). This compound is critical for researchers and manufacturers requiring precise control over side-chain reactivity and sequence assembly in complex peptide sequences. It is primarily utilized in the pharmaceutical and biotechnology sectors for the development of therapeutic peptides, peptidomimetics, and research-grade biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected intermediate for the automated or manual synthesis of complex peptide chains, particularly those containing serine and valine residues.
• Pharmaceutical R&D: Used in the research and development of novel therapeutic peptides targeting metabolic disorders, oncology, and infectious diseases.
• Peptidomimetic Design: Serves as a building block for creating modified peptide analogs with enhanced stability, bioavailability, or receptor affinity.
• Combinatorial Chemistry Libraries: Employed in the generation of diverse peptide libraries for high-throughput screening and drug discovery campaigns.
• Bioconjugation: Can be used in the synthesis of peptide segments intended for conjugation to proteins, antibodies, or other biomolecules.
• Academic Research: A valuable reagent for university and institutional labs studying peptide structure, function, and synthesis methodology.

Basic Information

Product Name	Fmoc-Val-Ser(Psime,Mepro)-Oh
CAS No.	186023-49-4
Molecular Formula	C27H34N2O7Si
Molecular Weight	526.66 g/mol
Synonyms	Fmoc-Val-Ser[Psi(Me,Pro)]-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-valyl-O-[1-methyl-1-(1-methylethyl)-1-silapropyl]-L-serine; Fmoc-Val-Ser(Psi(Me,Pro)OH; Fmoc-Val-Ser[Psi(Me,Pro)]OH; Fmoc-L-Valyl-O-(1-methyl-1-(1-methylethyl)-1-silapropyl)-L-serine; Fmoc-Val-Ser[Psi(Me,Pro)]-OH; Protected Fmoc-Val-Ser dipeptide; Silicon-based serine protecting group dipeptide.
EINECS	Contact for details

Quality Control

Our Fmoc-Val-Ser(Psime,Mepro)-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and MS for identity verification, to ensure it meets the high standards required for sensitive peptide synthesis applications. Certificates of Analysis (COA) detailing purity, chiral integrity, and impurity profiles are available for every lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Specific Rotation	-20° to -30° (c=1 in DMF)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.