Description

Z-D-Dap(Fmoc)-Oh is a protected amino acid derivative, specifically an Fmoc-protected form of the non-proteinogenic amino acid 2,3-diaminopropionic acid (Dap) with a D-configuration. This compound is a crucial building block in solid-phase peptide synthesis (SPPS), enabling the controlled incorporation of a diamino acid residue to create complex peptide architectures. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing novel peptide-based therapeutics, diagnostics, and research tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the Fmoc-strategy synthesis of peptides containing 2,3-diaminopropionic acid.
• Pharmaceutical Research: Used in the development of peptide drugs, enzyme inhibitors, and receptor ligands where the Dap side chain provides a site for further modification or conjugation.
• Bioconjugation: The free amino group on the side chain allows for selective labeling or linking to other molecules, such as fluorophores, biotin, or drug payloads.
• Chemical Biology Probes: Synthesis of tool compounds and probes to study protein-protein interactions and biological pathways.
• Material Science: Building block for the synthesis of peptidomimetics and functionalized polymers with specific chemical properties.

Basic Information

Item	Details
Product Name	Z-D-Dap(Fmoc)-Oh
CAS No.	185968-90-5
Molecular Formula	C₂₆H₂₄N₂O₆
Molecular Weight	460.48 g/mol
Synonyms	N2-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N3-[(benzyloxy)carbonyl]-D-2,3-diaminopropanoic acid; Fmoc-D-Dap(Z)-OH; (R)-2-(((Benzyloxy)carbonyl)amino)-3-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)propanoic acid; D-2,3-Diaminopropionic acid, N2-Fmoc, N3-Z; Z-D-2,3-diaminopropionic acid(Fmoc); Nα-Fmoc-Nβ-Cbz-D-2,3-diaminopropionic acid; Fmoc-D-Dap(Z)-OH
EINECS	Contact for details

Quality Control

Our Z-D-Dap(Fmoc)-Oh is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for sensitive research and development applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral analysis to confirm configuration. A detailed Certificate of Analysis (COA) specifying identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.