Description

Asimadoline-Hcl CAS NO 185951-07-9 is a selective κ-opioid receptor agonist, a high-purity pharmaceutical intermediate and research chemical of significant interest. Its primary value lies in its potent and specific pharmacological activity, making it a critical compound for advanced drug discovery and development programs. This product is essential for pharmaceutical R&D laboratories, academic research institutions, and manufacturers focused on developing novel analgesics and treatments for gastrointestinal disorders.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel κ-opioid receptor-targeting therapeutics.
• Analgesic Research: Used in preclinical studies to investigate non-addictive pathways for pain management.
• Gastrointestinal Motility Studies: Applied in research targeting functional bowel disorders like irritable bowel syndrome (IBS).
• Neuropharmacology: A vital tool for studying the central and peripheral nervous system's κ-opioid receptor systems.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Biochemical Assay Development: Utilized in creating and validating high-throughput screening assays for receptor binding studies.

Basic Information

Product Name	Asimadoline-Hcl
CAS No.	185951-07-9
Molecular Formula	C23H28N2O3 • HCl
Molecular Weight	424.94 g/mol
Synonyms	Asimadoline Hydrochloride; (S)-N-Methyl-N-[(1S)-1-phenyl-2-((3S)-3-hydroxypyrrolidin-1-yl)ethyl]-2-phenoxyacetamide hydrochloride; EMD 61753; EMD-61753; EMD61753; Asimadoline (Hydrochloride); (+)-Asimadoline Hydrochloride
EINECS	Contact for details

Quality Control

Our Asimadoline-Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral purity determination, and identity confirmation (IR, NMR) to ensure it meets the stringent requirements for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with in-house specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.