Description

Mca-Pro-Leu-Gly-Pro-D-Lys(Dnp)-Oh CAS NO 185698-23-1 is a specialized, sequence-defined synthetic peptide derivative. This compound is of significant value in biochemical and pharmaceutical research, primarily serving as a high-precision substrate or inhibitor for studying enzyme kinetics and protease activity. It is essential for researchers and developers in the fields of medicinal chemistry, proteomics, and drug discovery who require well-characterized, pure peptide tools for mechanistic studies and assay development.

Application

• Protease/Enzyme Substrate: Used as a specific, chromogenic or fluorogenic substrate for the study of matrix metalloproteinases (MMPs), collagenases, and other related proteolytic enzymes.
• Biochemical Assay Development: Serves as a critical component in the development of high-throughput screening (HTS) assays to identify and characterize potential enzyme inhibitors.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to design and optimize novel therapeutic agents targeting specific proteases.
• Academic & Industrial R&D: A key reagent in basic research within university laboratories and biopharmaceutical companies for investigating protein-protein interactions and enzymatic pathways.
• Quality Control Standard: Can be utilized as a reference standard in the quality control of enzyme preparations or related biopharmaceutical products.

Basic Information

Product Name	Mca-Pro-Leu-Gly-Pro-D-Lys(Dnp)-Oh
CAS No.	185698-23-1
Molecular Formula	C41H53N9O13
Molecular Weight	879.92 g/mol
Synonyms	Mca-PLGPK(Dnp)-OH; (7-Methoxycoumarin-4-yl)acetyl-Pro-Leu-Gly-Pro-D-Lys(2,4-Dinitrophenyl)-OH; Mca-Pro-Leu-Gly-Pro-D-Lys(Dnp); Fluorogenic MMP Substrate II; MMP Substrate II; CAS 185698-23-1; Mca-PLGPK(Dnp)
EINECS	Contact for details

Quality Control

Our Mca-Pro-Leu-Gly-Pro-D-Lys(Dnp)-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry for identity confirmation, and NMR for structural verification. We provide full traceability and a detailed Certificate of Analysis (COA) with every shipment, ensuring the material meets the stringent requirements for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Yellow to orange powder or solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Water Content (KF)	≤ 5.0 %
Solubility	Soluble in DMSO, DMF; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.