Description

(Z)-2'-Deoxy-2'-Ethoxycarbonylmethylene-3',5'-o-(1,1,3,3-Tetraisopropyldisiloxane-1,3-Diyl)Uridine is a sophisticated, protected nucleoside derivative, a critical building block in the synthesis of modified oligonucleotides. Its primary value lies in enabling precise chemical modifications to the ribose sugar backbone, which is essential for developing advanced therapeutic nucleic acids with enhanced stability and target affinity. This high-purity intermediate is indispensable for research and production teams in pharmaceutical development, particularly those focused on antisense oligonucleotides, siRNA, and other cutting-edge genetic medicines. The CAS number for this compound is provided in the table below.

Application

• Pharmaceutical Intermediate: A key protected monomer for the solid-phase synthesis of therapeutic oligonucleotides, including antisense drugs and siRNA.
• Antiviral Drug Research: Used in the development of nucleoside analogs targeting viral polymerases for potential antiviral therapies.
• Probe and Diagnostic Development: Serves as a modified building block for creating labeled DNA/RNA probes used in molecular diagnostics and research assays.
• Medicinal Chemistry: Enables structure-activity relationship (SAR) studies by allowing specific modifications to the oligonucleotide structure to optimize drug properties.
• Academic & Biotech R&D: Employed in research laboratories for studying nucleic acid chemistry, enzyme mechanisms, and developing novel gene-targeting tools.

Basic Information

Product Name	(Z)-2'-Deoxy-2'-Ethoxycarbonylmethylene-3',5'-o-(1,1,3,3-Tetraisopropyldisiloxane-1,3-Diyl)Uridine
CAS No.	185556-78-9
Molecular Formula	C28H48N2O8Si2
Molecular Weight	596.87 g/mol
Synonyms	2'-Deoxy-2'-ethoxycarbonylmethylene-3',5'-O-(1,1,3,3-tetraisopropyl-1,3-disiloxanediyl)uridine; 2'-Deoxy-2'-C-ethoxycarbonylmethyleneuridine 3',5'-cyclic TIPDS ether; 5'-O-(1,1,3,3-Tetraisopropyldisiloxan-1,3-diyl)-2'-deoxy-2'-C-ethoxycarbonylmethyleneuridine; TIPDS-protected 2'-C-allyluridine derivative; Uridine, 2'-deoxy-2'-(ethoxycarbonyl)methylene-3',5'-[1,1,3,3-tetraisopropyl-1,3-disiloxanediyl]-, (Z)-; CAS 185556-78-9
EINECS	Contact for details

Quality Control

Our (Z)-2'-Deoxy-2'-Ethoxycarbonylmethylene-3',5'-o-(1,1,3,3-Tetraisopropyldisiloxane-1,3-Diyl)Uridine is manufactured under strict quality systems suitable for pharmaceutical research and development. Each batch is subjected to rigorous analytical testing, including HPLC for purity and identity confirmation (typically ≥97% by HPLC), to ensure consistency and reliability. Certificates of Analysis (COA) detailing specific batch results are provided and can be tailored to meet the documentation requirements of GMP/GLP environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.