Description

Fmoc-Glu-Pna CAS NO 185547-51-7 is a protected amino acid derivative, specifically an Fmoc-protected glutamic acid linked to a p-nitroanilide (Pna) group. This compound is a critical building block in solid-phase peptide synthesis (SPPS), where it serves as a key reagent for the controlled incorporation of glutamic acid. It is essential for researchers and manufacturers developing complex peptides for pharmaceutical, diagnostic, and biochemical applications, ensuring high coupling efficiency and purity in the final sequence.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a protected glutamic acid derivative for the sequential assembly of peptide chains.
• Pharmaceutical Intermediate: In the research and development of therapeutic peptides targeting various diseases.
• Bioconjugation & Probe Development: For creating labeled peptides or enzyme substrates used in biochemical assays and diagnostics.
• Combinatorial Chemistry Libraries: As a building block for generating diverse peptide libraries for drug discovery screening.
• Academic & Industrial Research: For fundamental studies in peptide chemistry, enzymology, and molecular biology.
• Custom Peptide Service Providers: A staple raw material for CROs and CDMOs offering bespoke peptide synthesis services.

Basic Information

Product Name	Fmoc-Glu-Pna
CAS No.	185547-51-7
Molecular Formula	C26H23N3O7
Molecular Weight	489.48 g/mol
Synonyms	Fmoc-Glu(OtBu)-pNA; N-(9-Fluorenylmethoxycarbonyl)-L-glutamic acid 5-(4-nitroanilide); Fmoc-L-glutamic acid α-tert-butyl ester γ-(4-nitroanilide); Fmoc-Glu(OtBu)-4-nitroanilide; Nα-Fmoc-Nγ-(4-nitroanilido)-L-glutamic acid tert-butyl ester; Fmoc-Glu-ONp (common abbreviation); Fmoc-Glutamic acid 4-nitroanilide; Fmoc-Glu(OtBu)-pNA (Peptide Grade)
EINECS	Contact for details

Quality Control

Our Fmoc-Glu-Pna is manufactured under strict quality systems to ensure batch-to-batch consistency for sensitive peptide synthesis applications. Each lot undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation. Certificates of Analysis (COA) detailing purity, chiral integrity, and impurity profiles are provided to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This material is hygroscopic (moisture-sensitive); ensure containers are sealed tightly after each use to prevent degradation. For long-term storage, consider desiccant or under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.