Description

Fmoc-Lys(Dabsyl)-Oh CAS NO 185503-97-3 is a specialized, dual-labeled amino acid derivative designed for advanced peptide synthesis and biochemical research. This compound is critical for researchers and manufacturers requiring precise, fluorescent tagging and orthogonal protection strategies in complex molecular assembly. It is primarily utilized by pharmaceutical R&D teams, biotech companies, and academic laboratories focused on developing novel peptide-based therapeutics, diagnostic probes, and bioconjugation platforms.

Application

• Solid-Phase Peptide Synthesis (SPPS): Serves as a key building block for incorporating a fluorescent Dabsyl label and an acid-labile Fmoc protecting group into peptide chains.
• Fluorescent Peptide Probes: Used in the development of labeled peptides for fluorescence-based assays, receptor binding studies, and cellular imaging applications.
• Proteomics Research: Employed in the synthesis of custom peptide standards, substrates for enzyme studies, and activity-based probes.
• Bioconjugation & Linker Chemistry: Facilitates the site-specific attachment of peptides to other molecules, surfaces, or carriers via its carboxylic acid functional group.
• High-Throughput Screening (HTS): Integral for creating fluorescent-tagged peptide libraries used in drug discovery campaigns.
• Diagnostic Reagent Development: A precursor for components in diagnostic kits that rely on fluorescence detection.

Basic Information

Product Name	Fmoc-Lys(Dabsyl)-Oh
CAS No.	185503-97-3
Molecular Formula	C₄₀H₄₄N₆O₆S
Molecular Weight	724.89 g/mol
Synonyms	Fmoc-Lys(Dabsyl)-OH; Nα-Fmoc-Nε-(4-dimethylamino-3,5-dinitrophenyl)-L-lysine; Fmoc-L-lysine(Dabsyl)-OH; Fmoc-Lys(Dnp)-OH (common historical alias); N(6)-[4-(Dimethylamino)-3,5-dinitrophenyl]-N(2)-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-lysine; Fmoc-Lys(DABSYL)-OH; Fmoc-Lysine(Dabsyl) (abbreviation); (2S)-6-[[4-(Dimethylamino)-3,5-dinitrophenyl]amino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)hexanoic acid
EINECS	Contact for details

Quality Control

Our Fmoc-Lys(Dabsyl)-Oh is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for sensitive research applications. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This material is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to ambient conditions, moisture, or light should be avoided to maintain stability and purity. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	Yellow to orange powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.