Description

(Sar1,Ile4,8)-Angiotensin II is a synthetic, biologically active peptide analog of the endogenous vasoconstrictor hormone Angiotensin II, designed for enhanced stability and specificity in research applications. This modified peptide is a critical tool for investigating the renin-angiotensin system (RAS), which regulates blood pressure, fluid balance, and cardiovascular function. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in cardiovascular disease research, drug discovery, and biochemical assay development.

Application

• Cardiovascular Research: Used as a reference standard and agonist in studies of blood pressure regulation, vascular smooth muscle contraction, and heart failure mechanisms.
• Drug Discovery & Screening: Serves as a key ligand in high-throughput screening (HTS) assays to identify and characterize novel Angiotensin II receptor (AT1/AT2) antagonists and modulators.
• Biochemical & Pharmacological Studies: Employed to study receptor binding affinity, signal transduction pathways (e.g., G-protein coupling), and downstream cellular effects mediated by the RAS.
• In Vitro Diagnostic Development: Acts as a critical component in the calibration and validation of immunoassays and other diagnostic tests targeting angiotensin pathways.
• Academic & Preclinical Research: Facilitates fundamental research into hypertension, renal function, and the role of peptides in endocrine and paracrine signaling.

Basic Information

Product Name	(Sar1,Ile4,8)-Angiotensin II
CAS No.	185461-45-4
Molecular Formula	C49H69N13O11
Molecular Weight	1032.2 g/mol
Synonyms	[Sar¹,Ile⁴,Ile⁸]-Angiotensin II; Sarile; (Sar¹,Ile⁸)-Angiotensin II; Angiotensin II (1-8) heptapeptide analog; ATII antagonist peptide; H-Sar-Arg-Val-Tyr-Ile-His-Pro-Ile-OH; Sarmesin (related analog); Angiotensin II receptor ligand
EINECS	Contact for details

Quality Control

Our (Sar1,Ile4,8)-Angiotensin II is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with research-grade standards. Specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Assay (Peptide Content)	≥ 80%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO, acetic acid solution

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.