Description

Pentanoic Acid, 5-[(Carboxymethyl)[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino]-, 1-(1,1-Dimethylethyl) Ester is a sophisticated, protected amino acid derivative designed for advanced organic synthesis. This compound is a critical building block for the controlled assembly of peptides and other complex molecules, offering precise functional group protection. It is primarily utilized by research institutions and pharmaceutical developers engaged in the synthesis of novel therapeutic agents, bioactive peptides, and specialized fine chemicals.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled, sequential addition of amino acids, particularly where side-chain carboxyl group protection is required.
• Pharmaceutical Research & Development: Serves as a crucial building block in the synthesis of peptide-based drug candidates, prodrugs, and other active pharmaceutical ingredients (APIs).
• Bioconjugation Chemistry: Used to introduce specific, protected functional handles onto biomolecules for labeling, drug delivery, or diagnostic applications.
• Combinatorial Chemistry Libraries: Employed in the generation of diverse compound libraries for high-throughput screening in drug discovery programs.
• Academic & Industrial Research: A valuable reagent for synthetic chemists exploring new methodologies in peptide and heterocyclic chemistry.

Basic Information

Product Name	Pentanoic Acid, 5-[(Carboxymethyl)[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino]-, 1-(1,1-Dimethylethyl) Ester
CAS No.	185426-31-7
Molecular Formula	C25H29NO6
Molecular Weight	439.50 g/mol
Synonyms	Fmoc-Glu(OtBu)-OH; N-α-Fmoc-L-glutamic acid 5-tert-butyl ester; Fmoc-Glu(OtBu)-OH; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonylamino)pentanedioic acid 5-tert-butyl ester; Fmoc-L-glutamic acid 5-tert-butyl ester; Fmoc-Glu(OtBu); N-Fmoc-L-glutamic acid γ-tert-butyl ester; Fmoc-Glu(OtBu)-OH (Glutamic acid side-chain protected)
EINECS	Contact for details

Quality Control

Our production of this high-purity synthetic intermediate adheres to stringent quality protocols. Every batch is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to ensure structural identity and purity. We provide comprehensive Certificates of Analysis (COA) detailing all critical parameters, supporting compliance with research and development standards. Specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled temperature, ideally between 2°C and 8°C for long-term stability. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent degradation. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation [α]D20	Contact for details
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.