Description

2,3-Dihydro-6-(Trifluoromethoxy)-1H-Inden-1-One is a high-purity, advanced pharmaceutical intermediate featuring a unique indanone scaffold substituted with a trifluoromethoxy group. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of novel active pharmaceutical ingredients (APIs) with enhanced metabolic stability and bioavailability. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of central nervous system (CNS) agents, anti-inflammatory drugs, and other therapeutic small molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of novel drug candidates targeting neurological and inflammatory pathways.
• Organic Synthesis Building Block: Used in cross-coupling reactions, cyclizations, and functional group transformations to create complex molecular architectures.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies and high-throughput screening libraries.
• Agrochemical Intermediate: Potential use in the synthesis of advanced crop protection agents and pesticides.
• Material Science Precursor: Can be utilized in the development of specialty polymers and organic electronic materials.

Basic Information

Product Name	2,3-Dihydro-6-(Trifluoromethoxy)-1H-Inden-1-One
CAS No.	185388-85-6
Molecular Formula	C10H7F3O2
Molecular Weight	216.16 g/mol
Synonyms	6-(Trifluoromethoxy)-1-indanone; 6-(Trifluoromethoxy)indan-1-one; 1H-Inden-1-one, 2,3-dihydro-6-(trifluoromethoxy)-; 2,3-Dihydro-6-(trifluoromethoxy)-1H-inden-1-one; 6-Trifluoromethoxyindan-1-one; 185388-85-6; 6-(Trifluoromethoxy)indanone
EINECS	Contact for details

Quality Control

Our 2,3-Dihydro-6-(Trifluoromethoxy)-1H-Inden-1-One is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong oxidizing agents and strong bases. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.