Description

Fmoc-L-2-Pyridylalanine CAS NO 185379-40-2 is a specialized, non-natural amino acid derivative featuring a pyridyl side chain, protected with the 9-fluorenylmethoxycarbonyl (Fmoc) group. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the precise incorporation of a heterocyclic aromatic moiety to modulate peptide properties such as binding affinity, solubility, and stability. It is essential for researchers and manufacturers in pharmaceutical R&D, biotechnology, and advanced materials science who are developing novel peptide-based therapeutics, diagnostic tools, and functional biomaterials.

Application

• Solid-Phase Peptide Synthesis (SPPS): Primary building block for the automated synthesis of complex peptides containing the 2-pyridylalanine residue.
• Pharmaceutical Research & Development: Used in the discovery and development of novel peptide drugs, including enzyme inhibitors, receptor agonists/antagonists, and antimicrobial peptides.
• Chemical Biology & Proteomics: A key reagent for synthesizing peptide probes, substrates, and inhibitors to study protein function and protein-protein interactions.
• Peptide Library Construction: Enables the creation of diverse peptide libraries for high-throughput screening in drug discovery campaigns.
• Bioconjugation & Material Science: Serves as a precursor for creating functionalized peptides for surface immobilization, nanoparticle coating, and smart biomaterial design.
• Academic Research: Fundamental reagent for universities and research institutes studying peptide structure-activity relationships and folding.

Basic Information

Product Name	Fmoc-L-2-Pyridylalanine
CAS No.	185379-40-2
Molecular Formula	C24H20N2O4
Molecular Weight	400.43 g/mol
Synonyms	Fmoc-2-Pal-OH; Fmoc-L-2-Pyridyl-Ala-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-(2-pyridinyl)-L-alanine; (2S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-(pyridin-2-yl)propanoic acid; Fmoc-2-Pyridylalanine; Fmoc-L-(2-Pyridyl)alanine; Nα-Fmoc-L-2-pyridylalanine; Fmoc-2-Pal
EINECS	Contact for details

Quality Control

Our Fmoc-L-2-Pyridylalanine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment, chiral analysis to confirm enantiomeric integrity, and comprehensive spectroscopic identification (NMR, MS). A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.