Description

Fmoc-Gly-Pro-Hyp-Oh CAS NO 185213-75-6 is a protected tripeptide building block, specifically an Fmoc-protected derivative of the Glycine-Proline-Hydroxyproline sequence. This compound is essential for the solid-phase synthesis of complex collagen-like peptides and other biomimetic materials, where precise sequence control and orthogonal protection are required. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in peptide drug discovery and advanced biomaterial development.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected intermediate for the automated or manual assembly of collagen-model peptides and other structured sequences.
• Biomimetic Material Research: Used in the development of synthetic collagen, hydrogels, and scaffolds for tissue engineering and regenerative medicine applications.
• Pharmaceutical R&D: Serves as a crucial building block in the discovery and development of peptide-based therapeutics targeting various diseases.
• Chemical Biology Studies: Employed to create labeled or modified peptide probes for investigating protein-protein interactions and enzyme mechanisms.
• Fine Chemical Production: Acts as a high-value intermediate for the custom synthesis of specific peptide sequences for commercial and research purposes.

Basic Information

Product Name	Fmoc-Gly-Pro-Hyp-Oh
CAS No.	185213-75-6
Molecular Formula	C₂₉H₃₃N₃O₈
Molecular Weight	551.59 g/mol
Synonyms	Fmoc-Gly-Pro-Hyp-OH; Fmoc-Gly-Pro-Hyp; Fmoc-Gly-L-Pro-L-Hyp-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]glycyl-L-prolyl-trans-4-hydroxy-L-proline; (2S,4R)-1-[(2S)-1-[(2-{[(9H-Fluoren-9-ylmethoxy)carbonyl]amino}acetyl)pyrrolidin-2-yl]carbonyl]-4-hydroxypyrrolidine-2-carboxylic acid; Fmoc-Gly-Pro-trans-4-Hyp-OH; Fmoc-Gly-Pro-(4R)-Hyp-OH; Fmoc-Gly-Pro-Hydroxyproline-OH
EINECS	Contact for details

Quality Control

Our Fmoc-Gly-Pro-Hyp-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for peptide synthesis. Certificates of Analysis (COA) detailing purity, chiral integrity, and solvent content are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.