Description

Fmoc-L-Asn(Xan)-Oh is a protected amino acid derivative, specifically an Fmoc-protected L-asparagine with a xanthyl (Xan) side-chain protecting group. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled incorporation of asparagine while preventing unwanted side reactions. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing therapeutic peptides, diagnostic agents, and complex biomolecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key reagent for the sequential assembly of peptides using Fmoc-chemistry protocols.
• Pharmaceutical Research: Used in the discovery and development of novel peptide-based drugs and APIs (Active Pharmaceutical Ingredients).
• Bioconjugation: Serves as a modified amino acid for creating peptide-protein or peptide-small molecule conjugates.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening of bioactive peptide sequences.
• Proteomics & Biochemical Studies: Utilized to synthesize peptide fragments for antibody production, enzyme substrates, or protein interaction studies.
• Custom Peptide Service Providers: A fundamental raw material for CROs and CDMOs offering bespoke peptide synthesis.

Basic Information

Product Name	Fmoc-L-Asn(Xan)-Oh
CAS No.	185031-78-1
Molecular Formula	C₂₉H₂₈N₂O₆
Molecular Weight	500.55 g/mol
Synonyms	Fmoc-Asn(Xan)-OH; Fmoc-L-Asparagine(Xanthyl)-OH; N-α-Fmoc-N-β-xanthyl-L-asparagine; (2S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-(9H-xanthen-9-ylamino)-3-oxopropanoic acid; Fmoc-Asn(Xan)-OH; Fmoc-L-Asn(Xan)-OH; Fmoc-Asn(Xan)-OH; Fmoc-Asparagine(Xan)-OH
EINECS	Contact for details

Quality Control

Our Fmoc-L-Asn(Xan)-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research and cGMP applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for peptide synthesis building blocks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Specific Rotation	-20° to -25° (c=1 in DMF)
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.5%
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.