Description

2-Chloro-L-Phenylalanine is a halogenated derivative of the essential amino acid L-phenylalanine, distinguished by a chlorine atom at the 2-position of the aromatic ring. This structural modification makes it a valuable chiral building block and intermediate in the synthesis of more complex bioactive molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents and fine chemical synthesis.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in neurological and metabolic drug discovery.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide chemistry to incorporate a chlorinated phenylalanine residue, which can alter peptide conformation, stability, and receptor binding affinity.
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic studies to investigate amino acid metabolism and transport mechanisms.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for method development and validation in pharmaceutical analysis.
• Agrochemical Research: Acts as a precursor in the synthesis of specialized amino acid-based compounds for crop protection research.

Basic Information

Product Name	2-Chloro-L-Phenylalanine
CAS No.	185030-83-5
Molecular Formula	C9H10ClNO2
Molecular Weight	199.63 g/mol
Synonyms	(S)-2-Amino-3-(2-chlorophenyl)propanoic acid; L-2-Chlorophenylalanine; (2S)-2-Amino-3-(2-chlorophenyl)propanoic acid; 2-Chloro-L-phenylalanine; 2-Cl-L-Phe; 2-Chloro-L-Phe; (S)-2-Chlorophenylalanine; 2-Chloro-(S)-phenylalanine
EINECS	Contact for details

Quality Control

Our 2-Chloro-L-Phenylalanine is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the high standards required for research and pharmaceutical applications. A Certificate of Analysis (COA) detailing specific results for identity, purity, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept in a desiccated environment to prevent moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-Isomer)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.