Description

Fmoc-3,4-Dimethoxy-L-Phenylalanine is a protected, non-natural amino acid derivative essential for solid-phase peptide synthesis (SPPS). This high-purity building block is critical for researchers and manufacturers developing complex peptides for pharmaceutical and biotechnological applications. It is primarily used by peptide chemists in pharmaceutical R&D, biotechnology, and academic research to incorporate modified aromatic residues into peptide sequences, enabling the creation of novel therapeutic candidates and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid building block for the automated synthesis of complex peptides.
• Pharmaceutical Research & Development: Used to synthesize peptide-based drug candidates, including potential treatments for metabolic and neurological disorders.
• Peptide Library Construction: Essential for creating diverse combinatorial peptide libraries for high-throughput screening and drug discovery.
• Bioconjugation & Probe Development: Serves as a precursor for synthesizing fluorescently labeled or biotinylated peptides used in diagnostic assays and imaging.
• Structure-Activity Relationship (SAR) Studies: Incorporates modified phenylalanine analogs to study the impact of methoxy substitutions on peptide bioactivity and stability.
• Academic & Institutional Research: A fundamental reagent for studying peptide chemistry, protein engineering, and molecular biology in university and government labs.

Basic Information

Product Name	Fmoc-3,4-Dimethoxy-L-Phenylalanine
CAS No.	184962-88-7
Molecular Formula	C26H25NO6
Molecular Weight	447.48 g/mol
Synonyms	Fmoc-Dmp-OH; Fmoc-3,4-Dimethoxy-L-phenylalanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3,4-dimethoxy-L-phenylalanine; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-3-(3,4-dimethoxyphenyl)propanoic acid; Fmoc-L-3,4-dimethoxyphenylalanine; N-Fmoc-3,4-dimethoxy-L-phenylalanine; Fmoc-3,4-(MeO)2-Phe-OH
EINECS	Contact for details

Quality Control

Our Fmoc-3,4-Dimethoxy-L-Phenylalanine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, meeting the stringent requirements of peptide synthesis. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to industry best practices, and specifications can be aligned with research or cGMP standards as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥ 98.0%
Specific Rotation	-15.0° to -20.0° (c=1, DMF)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.