Description

Fibronectin Fragment (1954-1959) is a specific, bioactive peptide sequence derived from the cell-binding domain of human fibronectin. This fragment is critical for research and development in cell biology and biomaterials due to its high-affinity interaction with integrin receptors, promoting cell adhesion, spreading, and signaling. It is an essential reagent for scientists and manufacturers in the fields of regenerative medicine, tissue engineering, and advanced in vitro cell culture applications.

Application

• Cell Culture Substrate Coating: Used to functionalize surfaces (e.g., tissue culture plastic, glass, polymers) to enhance attachment and growth of primary cells and sensitive cell lines.
• Biomaterial and Scaffold Functionalization: Incorporated into hydrogels, 3D scaffolds, and synthetic matrices to create bioactive environments for tissue engineering.
• Integrin-Specific Research: Serves as a selective ligand in studies of integrin-mediated signaling pathways, cell migration, and mechanotransduction.
• Diagnostic Assay Development: Employed in the development of cell-based assays and biosensors to study cell adhesion and screen for bioactive compounds.
• Neural and Stem Cell Research: Supports the adhesion and differentiation of neural stem cells and other progenitor cell types in defined culture systems.
• Wound Healing Models: Applied in in vitro models to study fibroblast and keratinocyte behavior during the wound healing process.

Basic Information

Product Name	Fibronectin Fragment (1954-1959)
CAS No.	184895-13-4
Molecular Formula	C34H56N10O11
Molecular Weight	780.88 g/mol
Synonyms	Fibronectin Cell-Adhesion Peptide; Arg-Gly-Asp-Ser-Pro-Ala-Ser-Ser-Lys-Pro; RGDSPASSKP; Fibronectin (1954-1959); GRGDSP Peptide; Cyclo(-RGDfK-); Integrin Binding Peptide; Adhesion Peptide
EINECS	Contact for details

Quality Control

Our Fibronectin Fragment (1954-1959) is produced under stringent conditions to ensure batch-to-batch consistency and high biological activity. Quality is verified through comprehensive analytical methods including HPLC, mass spectrometry, and amino acid analysis. Certificates of Analysis (COA) detailing purity, sequence confirmation, and endotoxin levels are provided with every shipment to support your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Amino Acid Sequence	Arg-Gly-Asp-Ser-Pro-Ala-Ser-Ser-Lys-Pro
Molecular Weight	780.88 g/mol (Monoisotopic)
Water Content (KF)	≤ 5.0%
Endotoxin Level	< 1.0 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.