Description

Amyloid β-Protein (29-40) is a defined fragment of the amyloid beta peptide, a key component in Alzheimer's disease research. This high-purity synthetic peptide is critical for studying the aggregation mechanisms, neurotoxicity, and structural biology associated with amyloid plaques. It is an essential biochemical tool for researchers and developers in neuroscience, pharmaceutical discovery, and diagnostic assay development.

Application

• Neuroscience Research: Fundamental studies on amyloid beta aggregation kinetics, oligomer formation, and fibrillogenesis.
• Drug Discovery Screening: Used as a target or reagent in high-throughput assays to identify potential therapeutic compounds that inhibit aggregation.
• Antibody Development & Validation: Serves as a critical antigen for generating and characterizing antibodies specific to the C-terminal region of amyloid beta.
• Biophysical Studies: Employed in structural analysis using techniques like NMR, CD spectroscopy, and electron microscopy to understand peptide conformation.
• Diagnostic Assay Development: Used as a calibrator or control in the development of immunoassays (e.g., ELISA) for detecting amyloid beta variants in biological samples.
• Cell Culture & Model Systems: Application in cellular models to study peptide-induced cytotoxicity and neuroinflammation.

Basic Information

Product Name	Amyloid β-Protein (29-40)
CAS No.	184865-04-1
Molecular Formula	C58H89N15O16
Molecular Weight	1244.4 g/mol
Synonyms	Aβ(29-40); Amyloid β-Protein (29-40) fragment; β-Amyloid Peptide (29-40); Aβ29-40; Amyloid Beta (29-40); GAIIGLMVGGVV; H-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-OH
EINECS	Contact for details

Quality Control

Every batch of our Amyloid β-Protein (29-40) is synthesized and purified under stringent conditions to ensure the highest standards of identity, purity, and consistency. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic analyses, to ensure compliance with research-grade specifications. Certificates of Analysis (COA) detailing purity, molecular weight confirmation, and chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to minimize moisture absorption. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Molecular Weight (MS)	1244.4 ± 2 Da
Peptide Content	≥ 70%
Solubility	Soluble in water, DMSO, or acetonitrile/water mixtures

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.