Description

1-Fmoc-2-Azetidinecarboxylic Acid is a high-purity, protected amino acid derivative essential for advanced organic synthesis. This compound serves as a critical building block in the construction of complex peptide and peptidomimetic structures, offering precise control over molecular architecture. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery, medicinal chemistry, and the development of novel bioactive compounds.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key Fmoc-protected intermediate for the controlled, sequential assembly of peptides.
• Peptidomimetic Drug Discovery: Used to incorporate the constrained azetidine ring, which can improve metabolic stability, bioavailability, and binding affinity of lead compounds.
• Medicinal Chemistry Research: Serves as a versatile scaffold for creating focused libraries of novel small molecules targeting various disease pathways.
• Bioconjugation: Enables the site-specific modification of peptides and proteins for probe or therapeutic agent development.
• Chemical Biology Probes: Utilized in the synthesis of activity-based probes and other tools for studying enzyme function and biological mechanisms.
• Custom Synthesis Services: A fundamental starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for clients.

Basic Information

Product Name	1-Fmoc-2-Azetidinecarboxylic Acid
CAS No.	184763-07-3
Molecular Formula	C19H17NO4
Molecular Weight	323.34 g/mol
Synonyms	Fmoc-Aze-OH; 2-Azetidinecarboxylic acid, 1-[(9H-fluoren-9-ylmethoxy)carbonyl]-; 1-[(9-Fluorenylmethoxycarbonyl)azetidine-2-carboxylic acid]; 1-Fmoc-azetidine-2-carboxylic acid; N-Fmoc-azetidine-2-carboxylic acid; (2S)-1-[(9H-Fluoren-9-ylmethoxy)carbonyl]azetidine-2-carboxylic acid (for enantiopure form); Fmoc-Azetidine-2-COOH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]azetidine-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our 1-Fmoc-2-Azetidinecarboxylic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed specifications are provided for each lot to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation (if chiral)	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.