Description

(Ser(Tbu)6,Azagly10)-Lhrh CAS NO 184686-52-0 is a synthetic, modified analog of Luteinizing Hormone-Releasing Hormone (LHRH), engineered for enhanced stability and specific biological activity. This high-purity peptide is critical for advanced research in endocrinology and the development of targeted therapeutic agents. It is primarily utilized by pharmaceutical R&D teams, biotechnology companies, and academic research institutions focused on neuroendocrinology, oncology, and reproductive medicine.

Application

• Pharmaceutical Research & Development: Serves as a key reference standard and active pharmaceutical ingredient (API) in the development of novel hormone therapies and diagnostics.
• Endocrinology Studies: Used in vitro and in vivo to study the hypothalamic-pituitary-gonadal axis, receptor binding, and signal transduction mechanisms.
• Oncology Research: Investigated for applications in hormone-dependent cancers, such as prostate and breast cancer, due to its modified LHRH agonist/antagonist properties.
• Peptide Chemistry & Conjugation: Acts as a sophisticated building block for creating peptide-drug conjugates or labeled probes for imaging studies.
• Biochemical Assay Development: Employed as a critical component in the development and validation of high-sensitivity immunoassays and receptor binding assays.
• Academic & Institutional Research: Supports fundamental research in neurobiology, reproductive science, and peptide structure-activity relationships (SAR).

Basic Information

Product Name	(Ser(Tbu)6,Azagly10)-Lhrh
CAS No.	184686-52-0
Molecular Formula	C64H89N17O13
Molecular Weight	1280.5 g/mol
Synonyms	Azagly10-LHRH; [Azagly10]LHRH; LHRH (6-Ser(tBu), 10-Azagly); Luteinizing Hormone-Releasing Hormone (6-Ser(O-t-butyl), 10-Azaglycine) analog; Gonadorelin (6-Ser(tBu), 10-Azagly) analog; Pyro-Glu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Azagly-NH2 (with Ser(tBu) at position 6); Modified LHRH Peptide; LHRH Agonist/Antagonist Analog
EINECS	Contact for details

Quality Control

Every batch of (Ser(Tbu)6,Azagly10)-Lhrh is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We ensure compliance with high-purity standards typical for pharmaceutical-grade peptides. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and conformance to agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Assay (HPLC)	≥ 98.0% (on anhydrous basis)
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%
Acetate Content (HPIC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.