Description

4-(Difluoromethoxy)-3-Fluorophenol is a high-purity fluorinated phenolic intermediate of significant importance in advanced organic synthesis. This compound matters for its role as a critical building block in the development of active pharmaceutical ingredients (APIs) and agrochemicals, where its unique difluoromethoxy and fluorine substituents impart desirable biological and physicochemical properties. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce fluorinated motifs into complex molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and anti-inflammatory therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides, where fluorination enhances activity and environmental stability.
• Liquid Crystal Materials: Serves as a precursor for fluorinated monomers used in the manufacture of high-performance liquid crystal displays (LCDs).
• Polymer Modification: Incorporation into polymer backbones to alter thermal stability, chemical resistance, and surface properties.
• Organic Electronics: Potential building block for materials used in organic light-emitting diodes (OLEDs) and semiconductors.
• Chemical Research: Valuable reagent in academic and industrial laboratories for exploring new fluorination methodologies and structure-activity relationships.

Basic Information

Product Name	4-(Difluoromethoxy)-3-Fluorophenol
CAS No.	184162-48-9
Molecular Formula	C7H5F3O2
Molecular Weight	178.11 g/mol
Synonyms	3-Fluoro-4-(difluoromethoxy)phenol; 4-(Difluoromethoxy)-3-fluorophenol; Phenol, 3-fluoro-4-(difluoromethoxy)-; 3-Fluoro-4-difluoromethoxyphenol; 184162-48-9; 4-Difluoromethoxy-3-fluorophenol
EINECS	Contact for details

Quality Control

Our 4-(Difluoromethoxy)-3-Fluorophenol is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Production adheres to cGMP guidelines where applicable, and each lot is supported by a comprehensive Certificate of Analysis (COA). Our rigorous quality testing includes identity confirmation, purity assay, and detailed impurity profiling to meet the exacting standards of pharmaceutical and agrochemical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents, strong bases, and sources of ignition. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.