Description

Biotinyl-Amyloid β-Protein (1-40) is a biotin-conjugated peptide fragment of the amyloid precursor protein, a key molecule in neurological research. This modified peptide is essential for high-sensitivity detection and isolation studies, particularly in the investigation of Alzheimer's disease pathology. It is primarily utilized by research institutions, diagnostic developers, and pharmaceutical companies engaged in neuroscience, biomarker discovery, and therapeutic target validation.

Application

• Biomarker Research & Assay Development: Used as a critical capture or detection reagent in ELISA, Western blot, and other immunoassays for quantifying amyloid beta species.
• Neurodegenerative Disease Studies: Fundamental tool for Alzheimer's disease research, enabling the study of Aβ aggregation, toxicity, and clearance mechanisms.
• Drug Discovery & Screening: Serves as a target substrate in high-throughput screening (HTS) platforms to identify potential therapeutic compounds that inhibit Aβ aggregation or promote its degradation.
• Affinity Purification & Pull-Down Assays: Leverages the strong biotin-streptavidin interaction for isolating and characterizing Aβ-binding proteins, antibodies, or other interacting molecules from complex biological samples.
• Diagnostic Kit Manufacturing: Incorporated as a standardized antigen in the production of in-vitro diagnostic (IVD) kits for clinical and research use.
• Cell Culture & In Vitro Modeling: Applied in cellular models to study the effects of amyloid beta on neuronal health, synaptic function, and inflammatory responses.

Basic Information

Product Name	Biotinyl-Amyloid β-Protein (1-40)
CAS No.	183906-14-1
Molecular Formula	C207H317N55O58S
Molecular Weight	~4329.2 g/mol
Synonyms	Biotin-Aβ(1-40); Biotin-Amyloid β-Protein (1-40); Biotinylated Aβ40; Biotin-Aβ40; Biotin-conjugated Amyloid Beta (1-40); N-Biotinyl-Aβ(1-40); Biotinyl-DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV
EINECS	Contact for details

Quality Control

Our Biotinyl-Amyloid β-Protein (1-40) is produced under stringent conditions to ensure batch-to-batch consistency and high biological activity. Each lot undergoes comprehensive analytical characterization, including HPLC for purity and mass spectrometry for identity confirmation. Certificates of Analysis (COA) detailing purity, peptide content, and performance data are provided to support your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. Aliquot into single-use quantities to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 70% (by weight)
Molecular Weight	4329.2 ± 2.0 Da (by MS)
Solubility	Soluble in DMSO, dilute aqueous acetic acid, or buffer
Endotoxin Level	< 1.0 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.